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Details

Stereochemistry UNKNOWN
Molecular Formula C10H12ClNO4
Molecular Weight 245.66
Optical Activity ( - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORPHENESIN CARBAMATE, (-)-

SMILES

NC(=O)OCC(O)COC1=CC=C(Cl)C=C1

InChI

InChIKey=SKPLBLUECSEIFO-UHFFFAOYSA-N
InChI=1S/C10H12ClNO4/c11-7-1-3-9(4-2-7)15-5-8(13)6-16-10(12)14/h1-4,8,13H,5-6H2,(H2,12,14)

HIDE SMILES / InChI

Molecular Formula C10H12ClNO4
Molecular Weight 245.66
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms. Сhlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle. It also has antifungal and some antibacterial properties. The major adverse effects are drowsiness and dizziness.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
MAOLATE
Curative
MAOLATE

Cmax

ValueDoseCo-administeredAnalytePopulation
14.9 μg/mL
2 g single, oral
CHLORPHENESIN CARBAMATE serum
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
84 μg × h/mL
2 g single, oral
CHLORPHENESIN CARBAMATE serum
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
0.44 h
2 g single, oral
CHLORPHENESIN CARBAMATE serum
Homo sapiens

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as perpetrator​

PubMed

Sample Use Guides

In Vivo Use Guide
for adults is 1.6 to 2.4 gm given in divided doses
Route of Administration: Oral
In Vitro Use Guide
chlorphenesin carbamate (CPC) has an apparent depressing action on the spinal neuron. CPC caused marked hyperpolarizations and depressed spontaneous activities in both of the primary afferent terminals (PAT) and motoneurons (MN).
Substance Class Chemical
Record UNII
HQC4WI89YG
Record Status Validated (UNII)
Record Version