DAPLUSIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 04:37:51 GMT 2025` Edited by `admin` on `Wed Apr 02 04:37:51 GMT 2025`
Nucleic Acid Type	RNAI
Sequence Type	COMPLETE
Record UNII	HP2ZTB8W0F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

daplusiran [INN]

Preferred Name

English

DAPLUSIRAN

Official Name

English

RNA, (AM-SP-(2'-DEOXY-2'-FLUORO)G-SP-AM-SP-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)U-GM-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)A-GM-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)G-UM-(2'-DEOXY-2'-FLUORO)C-CM-AM-SP-CM),

Common Name

English

DAPLUSIRAN [USAN]

Common Name

English

Code System Code Type Description

SMS_ID

300000029018

Created by admin on Wed Apr 02 04:37:51 GMT 2025 , Edited by admin on Wed Apr 02 04:37:51 GMT 2025

PRIMARY

USAN

KL-34

Created by admin on Wed Apr 02 04:37:51 GMT 2025 , Edited by admin on Wed Apr 02 04:37:51 GMT 2025

PRIMARY

NCI_THESAURUS

C175765

Created by admin on Wed Apr 02 04:37:51 GMT 2025 , Edited by admin on Wed Apr 02 04:37:51 GMT 2025

PRIMARY

INN

11468

Created by admin on Wed Apr 02 04:37:51 GMT 2025 , Edited by admin on Wed Apr 02 04:37:51 GMT 2025

PRIMARY

FDA UNII

HP2ZTB8W0F

Created by admin on Wed Apr 02 04:37:51 GMT 2025 , Edited by admin on Wed Apr 02 04:37:51 GMT 2025

PRIMARY

CAS

2202783-35-3

Created by admin on Wed Apr 02 04:37:51 GMT 2025 , Edited by admin on Wed Apr 02 04:37:51 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_8;1_12-1_21;2_1;2_3;2_5;2_7;2_9;2_11;2_13;2_15;2_17;2_19-2_21	30 / 42
2'-Fluoro-Ribose	1_9-1_11;2_2;2_4;2_6;2_8;2_10;2_12;2_14;2_16;2_18	12 / 42

Linkage	Site Range	Site Count
Phosporothioate	2_2-2_4;2_21	4 / 40
Phosphate	1_2-1_21;2_5-2_20	36 / 40

Related Record Type Details


					HP2ZTB8W0F

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_21]	3'-TERMINUS			UNSPECIFIED SUBSTANCE	42383cde (not in database)