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Details

Stereochemistry ACHIRAL
Molecular Formula 2C9H18NS2.Zn
Molecular Weight 474.161
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC DIBUTYLDITHIOCARBAMATE

SMILES

[Zn++].CCCCN(CCCC)C([S-])=S.CCCCN(CCCC)C([S-])=S

InChI

InChIKey=BOXSVZNGTQTENJ-UHFFFAOYSA-L
InChI=1S/2C9H19NS2.Zn/c2*1-3-5-7-10(9(11)12)8-6-4-2;/h2*3-8H2,1-2H3,(H,11,12);/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula C9H19NS2
Molecular Weight 205.384
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Zn
Molecular Weight 65.409
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/689578 | https://www.ncbi.nlm.nih.gov/pubmed/16088893

Zinc dibutyldithiocarbamate (Zn DBDTC) is a vulcanization accelerator for natural rubber and latex and a stabilizer for rubber-based adhesive systems, isobutylene-isoprene copolymers and polypropylene. It is used in a number of rubber and rubber-based materials for food packaging and food handling, e.g. conveyor belts. Zinc dibutyldithiocarbamate (Zn DBDTC) is contact allergens that cross-react in some individuals. Zinc dibutyldithiocarbamate, like many low-molecular-weight contact allergens, can only trigger an immune response when bound to a protein in the form of an immunogenic protein–hapten complex. Haptenation of epidermally relevant skin proteins by Zinc dibutyldithiocarbamate has not been reported despite the numerous studies on the disposition and systemic toxicity of Zinc dibutyldithiocarbamate. The chelating properties of the dithiocarbamate ligand have been proposed to be responsible for the modification of some metalloproteins and metalloenzymes

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

In Vivo Use Guide
Groups of 15 male and 15 female rats were given diets contain!ng 0 (control), 100, 500 or 2500 ppm ZnDBDTC for 17wk.
Route of Administration: Oral
Model materials of three rubber sheets (Sample C contained ZDBC; thickness, 1 mm) were prepared. Materials were cut into approximately 2 x 15 mm pieces. The pieces (1 g) were put into a centrifuge tube, and 10 mL MEM supplemented with 5% FCS, nonessential amino acids, and 1 mM sodium pyruvate (5% FCS-GMNP) was added. After incubation at 37°C in a humidified atmosphere for 24 h, the extract, designated 100%, was decanted and serially diluted with 5% FCS-GMNP to give 80%, 64%, 51%, and 41% extracts.
Substance Class Chemical
Created
by admin
on Thu Jul 06 11:54:51 UTC 2023
Edited
by admin
on Thu Jul 06 11:54:51 UTC 2023
Record UNII
HNM5J934VP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZINC DIBUTYLDITHIOCARBAMATE
INCI  
INCI  
Official Name English
NSC-36548
Code English
ZINC, BIS(DIBUTYLDITHIOCARBAMATO)- [HSDB]
Common Name English
ZINC, BIS(DIBUTYLCARBAMODITHIOATO-S,S')-
Common Name English
ZINC DIBUTYLDITHIOCARBAMATE [INCI]
Common Name English
ZINCDIBUTYLDITHIOCARBAMATE
Common Name English
ZINC BIS(DIBUTYLDITHIOCARBAMATE)
Systematic Name English
NSC-3880
Code English
Classification Tree Code System Code
NDF-RT N0000185508
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID0021462
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
HSDB
2906
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
CAS
136-23-2
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
CHEBI
144323
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
NSC
3880
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
NSC
36548
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
MESH
C017801
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
DAILYMED
HNM5J934VP
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
EVMPD
SUB61027
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
NDF-RT
N0000175629
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY Increased Histamine Release [PE]
RXCUI
1426942
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY RxNorm
NDF-RT
N0000184306
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY Cell-mediated Immunity [PE]
PUBCHEM
8684
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
FDA UNII
HNM5J934VP
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
SMS_ID
100000134268
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
DRUG BANK
DB14194
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
NDF-RT
N0000171131
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY Allergens [Chemical/Ingredient]
ECHA (EC/EINECS)
205-232-8
Created by admin on Thu Jul 06 11:54:52 UTC 2023 , Edited by admin on Thu Jul 06 11:54:52 UTC 2023
PRIMARY
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