Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H12N4O4 |
| Molecular Weight | 252.2267 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@H](C[C@@H]1O)N2C=NC3=C2N=CNC3=O
InChI
InChIKey=VGONTNSXDCQUGY-RRKCRQDMSA-N
InChI=1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
| Molecular Formula | C10H12N4O4 |
| Molecular Weight | 252.2267 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase. | 1976 Dec 23 |
|
| Liquid-chromatographic study of purine metabolism abnormalities in purine nucleoside phosphorylase deficiency. | 1996 Feb |
|
| Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs. | 1998 Feb |
|
| Deoxyadenosine metabolism in a human colon-carcinoma cell line (LoVo) in relation to its cytotoxic effect in combination with deoxycoformycin. | 1998 Mar 2 |
|
| UVB-specific regulation of gene expression in human melanocytic cells: cell cycle effects and implication in the generation of melanoma. | 1998 Nov 9 |
|
| Synthesis of N2-substituted deoxyguanosine nucleosides from 2-fluoro-6-O-(trimethylsilylethyl)-2'-deoxyinosine. | 2001 May |
|
| Sequencing in the presence of betaine: Improvement in sequencing of the localized repeat sequence regions. | 2002 Dec |
|
| Recent advances in structure and function of cytosolic IMP-GMP specific 5'-nucleotidase II (cN-II). | 2006 Nov |
|
| Clastogenic factors as potential biomarkers of increased superoxide production. | 2007 Dec 11 |
|
| Adenosine and lymphocyte regulation. | 2007 Mar |
|
| Successful HLA-identical hematopoietic stem cell transplantation in a patient with purine nucleoside phosphorylase deficiency. | 2007 Nov |
|
| Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition. | 2007 Oct 30 |
|
| In vitro and in vivo reversal of resistance to 5-fluorouracil in colorectal cancer cells with a novel stealth double-liposomal formulation. | 2007 Oct 8 |
|
| The human vaginal bacterial biota and bacterial vaginosis. | 2008 |
|
| Self-Avoiding Molecular Recognition Systems (SAMRS). | 2008 |
|
| Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases. | 2008 Apr 4 |
|
| 7-Deaza-2'-deoxyinosine: a nucleoside showing ambiguous base-pairing properties against the four canonical DNA constituents. | 2008 Aug |
|
| Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: a system for the structure determination of lesion-containing DNA. | 2008 Aug 6 |
|
| Effect of cardiovascular drugs on adenosine deaminase activity. | 2008 Dec-2009 Jan |
|
| Removal of deoxyinosine from the Escherichia coli chromosome as studied by oligonucleotide transformation. | 2008 Feb 1 |
|
| Universal primers that amplify RNA from all three flavivirus subgroups. | 2008 Jan 24 |
|
| Blocking primers to enhance PCR amplification of rare sequences in mixed samples - a case study on prey DNA in Antarctic krill stomachs. | 2008 Jul 20 |
|
| Pegademase bovine (PEG-ADA) for the treatment of infants and children with severe combined immunodeficiency (SCID). | 2009 |
|
| Development of a real-time reverse-transcription PCR for the detection and simultaneous pathotyping of Newcastle disease virus isolates using a novel probe. | 2009 |
|
| Limited duration of vaccine poliovirus and other enterovirus excretion among human immunodeficiency virus infected children in Kenya. | 2009 Aug 23 |
|
| Efficient recognition of an unpaired lesion by a DNA repair glycosylase. | 2009 Dec 16 |
|
| Modeling of Escherichia coli Endonuclease V structure in complex with DNA. | 2009 Feb |
|
| Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients. | 2009 Jul-Aug |
|
| Borrelia burgdorferi bb0426 encodes a 2'-deoxyribosyltransferase that plays a central role in purine salvage. | 2009 Jun |
|
| O6-(benzotriazol-1-yl)inosine derivatives for C6 modification of purine nucleosides. | 2009 Mar |
|
| The Base Excision Repair system of Salmonella enterica serovar typhimurium counteracts DNA damage by host nitric oxide. | 2009 May |
|
| Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal. | 2009 May |
|
| Molecular characterisation and genetic mapping of candidate genes for qualitative disease resistance in perennial ryegrass (Lolium perenne L.). | 2009 May 19 |
|
| IGF-I activates caspases 3/7, 8 and 9 but does not induce cell death in colorectal cancer cells. | 2009 May 21 |
|
| High genotypic diversity and a novel variant of human cytomegalovirus revealed by combined UL33/UL55 genotyping with broad-range PCR. | 2009 Nov 26 |
|
| Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. | 2009 Sep 18 |
|
| Template-directed ligation of tethered mononucleotides by t4 DNA ligase for kinase ribozyme selection. | 2010 Aug 24 |
|
| Constraint-based modeling analysis of the metabolism of two Pelobacter species. | 2010 Dec 23 |
|
| Determination of serum adenosine deaminase and xanthine oxidase levels in patients with crimean-congo hemorrhagic fever. | 2010 Jul |
|
| Successful pyrosequencing of GC-rich DNA sequences by partial substitution of deoxyguanosine with deoxyinosine. | 2010 Jun |
|
| Role of Adenosine Deaminase Estimation in Differentiation of Tuberculous and Non-tuberculous Exudative Pleural Effusions. | 2010 Mar 20 |
|
| Sensitivity, specificity, negative and positive predictive values of adenosine deaminase in patients of tubercular and non-tubercular serosal effusion in India. | 2010 May 19 |
|
| ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells. | 2010 Nov 28 |
|
| DNA suspension arrays: silencing discrete artifacts for high-sensitivity applications. | 2010 Nov 8 |
|
| Adenosine Deaminase Levels in CSF of Tuberculous Meningitis Patients. | 2010 Oct 11 |
|
| Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma. | 2010 Oct 22 |
|
| Development of a real-time quantitative PCR assay for detection of a stable genomic region of BK virus. | 2010 Oct 29 |
|
| Potential short-term use of oral cladribine in treatment of relapsing-remitting multiple sclerosis. | 2010 Oct 5 |
|
| Endonuclease V-mediated deoxyinosine excision repair in vitro. | 2010 Oct 5 |
|
| Electrochemical genotyping and detection of single-nucleotide polymorphisms based on junction-probe containing 2'-deoxyinosine. | 2010 Oct 7 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 03:27:49 GMT 2023
by
admin
on
Sat Dec 16 03:27:49 GMT 2023
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| Record UNII |
HN0RQ6SBWQ
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| Record Status |
Validated (UNII)
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| Record Version |
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135398593
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28997
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890-38-0
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DB02380
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212-964-1
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HN0RQ6SBWQ
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
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