Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H30O11 |
| Molecular Weight | 458.4563 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 12 / 12 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12O[C@]3([H])C=C(C)C(=O)[C@@H](O)[C@]3(CO)[C@@](C)(C[C@H]1O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@]25CO5
InChI
InChIKey=PUMXWMGECQIOGB-SMSDQXDJSA-N
InChI=1S/C21H30O11/c1-8-3-11-20(6-23,16(28)12(8)24)19(2)4-9(17(32-11)21(19)7-29-21)30-18-15(27)14(26)13(25)10(5-22)31-18/h3,9-11,13-18,22-23,25-28H,4-7H2,1-2H3/t9-,10-,11-,13-,14+,15-,16-,17-,18-,19-,20-,21+/m1/s1
| Molecular Formula | C21H30O11 |
| Molecular Weight | 458.4563 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 12 / 12 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Deoxynivalenol-3-glucoside (DON-3-glucoside) is a deoxynivalenol (DON) plant conjugate that is widely found in cereal products. D3G was also was detected when Trichoderma was confronted with F. graminearum. D3G is not toxic by itself but may pose a risk of gut health through its reconversion into its parent mycotoxin DON.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Detoxification of Deoxynivalenol via Glycosylation Represents Novel Insights on Antagonistic Activities of Trichoderma when Confronted with Fusarium graminearum. | 2016 Nov 15 |
|
| Fate of deoxynivalenol and deoxynivalenol-3-glucoside during cereal-based thermal food processing: a review study. | 2017 Feb |
Sample Use Guides
The toxicity of deoxynivalenol-3-β-D-glucoside (D3G) and DON (0-10 µM) was studied in vitro, on the human intestinal Caco-2 cell line. First, an in silico analysis revealed that D3G, contrary to DON, was unable to bind to the A-site of the ribosome peptidyl transferase center, the main targets for DON toxicity. Accordingly, D3G did not activate JNK and P38 MAPKs in treated Caco-2 cells and did not alter viability and barrier function on cells, as measured by the trans-epithelial electrical resistance.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:03:43 GMT 2023
by
admin
on
Sat Dec 16 09:03:43 GMT 2023
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| Record UNII |
HKI01R84M9
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| Record Status |
Validated (UNII)
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| Record Version |
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HKI01R84M9
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71312510
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DTXSID10891865
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