TELMAPITANT

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H23F6N3O3
Molecular Weight	515.4481
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H](OC[C@]1(CC[C@]2(CN1)NC(=O)NC2=O)C3=CC=CC=C3)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F

InChI

InChIKey=NWZTURJOOOFKAS-KHIBUBOWSA-N

InChI=1S/C24H23F6N3O3/c1-14(15-9-17(23(25,26)27)11-18(10-15)24(28,29)30)36-13-22(16-5-3-2-4-6-16)8-7-21(12-31-22)19(34)32-20(35)33-21/h2-6,9-11,14,31H,7-8,12-13H2,1H3,(H2,32,33,34,35)/t14-,21-,22-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H23F6N3O3
Molecular Weight	515.4481
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.genome.jp/dbget-bin/www_bget?dr:D10391

Telmapitant, a neurokinin NK1 antagonist, was developed as an anti-emetic agent that has never been marketed. Information about the current use of the telmapitant is not available.

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:53:46 GMT 2023` Edited by `admin` on `Sat Dec 16 05:53:46 GMT 2023`
Record UNII	HJ5FE4153B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TELMAPITANT

Official Name

English

Telmapitant [WHO-DD]

Common Name

English

telmapitant [INN]

Common Name

English

1,3,7-TRIAZASPIRO(4.5)DECANE-2,4-DIONE, 8-(((1R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHOXY)METHYL)-8-PHENYL-, (5R,8S)-

Systematic Name

English

(5R,8S)-8-(((1R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHOXY)METHYL)-8-PHENYL-1,3,7- TRIAZASPIRO(4.5)DECANE-2,4-DIONE

Systematic Name

English

TELMAPITANT [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C267