FLUCICLATIDE F-18

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C75H115FN18O27S3
Molecular Weight	1815.016
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)COCC(=O)NCCOCCOCCOCCNC(=O)[C@@H]1CSCC(=O)N[C@@H](CCCCNC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCNC(=O)CO\N=C\C2=CC=C([18F])C=C2)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC3=O)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N1

InChI

InChIKey=VXFFXZSNVKXXIB-JZNCAEBOSA-N

InChI=1S/C75H115FN18O27S3/c76-52-13-11-51(12-14-52)39-87-121-45-65(100)83-19-23-113-27-31-117-34-36-118-35-33-116-30-26-112-22-18-82-64(99)44-120-43-62(97)80-15-5-4-9-54-70(106)93-58-47-123-124-48-59(94-72(108)56(38-67(102)103)89-61(96)40-86-68(104)53(90-73(58)109)10-6-16-85-75(78)79)74(110)91-55(37-50-7-2-1-3-8-50)71(107)92-57(46-122-49-66(101)88-54)69(105)84-20-24-114-28-32-115-29-25-111-21-17-81-63(98)42-119-41-60(77)95/h1-3,7-8,11-14,39,53-59H,4-6,9-10,15-38,40-49H2,(H2,77,95)(H,80,97)(H,81,98)(H,82,99)(H,83,100)(H,84,105)(H,86,104)(H,88,101)(H,89,96)(H,90,109)(H,91,110)(H,92,107)(H,93,106)(H,94,108)(H,102,103)(H4,78,79,85)/b87-39+/t53-,54-,55-,56-,57-,58-,59-/m0/s1/i76-1

HIDE SMILES / InChI

Molecular Formula	C75H115FN18O27S3
Molecular Weight	1815.016
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	6
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67530281 | https://www.ncbi.nlm.nih.gov/pubmed/18483090 | https://www.ncbi.nlm.nih.gov/pubmed/21321268

FLUCICLATIDE F-18 is an 18F-radiolabelled synthetic cyclic peptide containing an RGD motif (Arg-Gly-Asp). It may be used as a tracer in positron emission tomography (PET) imaging. The RGD motif of FLUCICLATIDE F-18 selectively binds to the alpha-V/beta-3 integrin, upregulated on tumor cells and endothelial cells of tumor vasculature. Integrins play an important role in tumor angiogenesis and metastasis. Thus, FLUCICLATIDE F-18 is a potential biomarker of therapeutic response to antiangiogenic inhibitors.

Originator

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:28:47 GMT 2023` Edited by `admin` on `Sat Dec 16 01:28:47 GMT 2023`
Record UNII	HH9UGU71P8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLUCICLATIDE F-18

Common Name

English

Fluciclatide (18f) [WHO-DD]

Common Name

English

AH-111585 F-18

Code

English

(18F)AH-111585

Code

English

(18F)AH111585

Code

English

FLUCICLATIDE F 18

Official Name

English

FLUCICLATIDE (F-18)

Common Name

English

FLUCICLATIDE (18F)

Official Name

English

fluciclatide (¹⁸F) [INN]

Common Name

English

FLUCICLATIDE F 18 [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2124