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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 15:22:29 GMT 2025
Edited
by admin
on Wed Apr 02 15:22:29 GMT 2025
Protein Type RECEPTOR
Protein Sub Type ACETYLCHOLINE RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
HG7V4AMY2Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Neuronal acetylcholine receptor subunit alpha-4/Neuronal acetylcholine receptor subunit beta-2
Preferred Name English
?4?2 Nicotinic acetylcholine receptor
Common Name English
?4?2 nAChR
Common Name English
Code System Code Type Description
FDA UNII
HG7V4AMY2Z
Created by admin on Wed Apr 02 15:22:29 GMT 2025 , Edited by admin on Wed Apr 02 15:22:29 GMT 2025
PRIMARY
UNIPROT
P43681
Created by admin on Wed Apr 02 15:22:29 GMT 2025 , Edited by admin on Wed Apr 02 15:22:29 GMT 2025
PRIMARY
UNIPROT
P17787
Created by admin on Wed Apr 02 15:22:29 GMT 2025 , Edited by admin on Wed Apr 02 15:22:29 GMT 2025
PRIMARY
From To
5_130 5_144
4_130 4_144
1_133 1_147
3_133 3_147
2_133 2_147
1_197 1_198
3_197 3_198
2_197 2_198
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_29
N 1_79
N 1_146
N 2_29
N 2_79
N 2_146
N 3_29
N 3_79
N 3_146
N 4_26
N 4_143
N 4_460
N 5_26
N 5_143
N 5_460
Related Record Type Details
Structure of XTRA F-18
RADIOLIGAND->TARGET
Structure of SOFINICLINE
AGONIST -> TARGET
Structure of 5-Methyl-A-85380 C-11
RADIOLIGAND->TARGET
Ki Values for Inhibiting ()-3H-Cytisine Binding to Rat Brain Synaptosomal Membranes
Ki
Structure of ISPRONICLINE
PARTIAL AGONIST->TARGET
Structure of A-85380 5-I-123
RADIOLIGAND->TARGET
Kd
Structure of TEBANICLINE
AGONIST -> TARGET
Structure of XTRA
INHIBITOR -> TARGET
Structure of A-85380 5-I-125
RADIOLIGAND->TARGET
Kd
Structure of DIANICLINE
PARTIAL AGONIST->TARGET
Structure of RIVANICLINE
PARTIAL AGONIST->TARGET
Selective partial agonist. Radioligand [3H]-L-nicotine binding in membranes from rat cerebral cortex
Ki
Structure of POZANICLINE
PARTIAL AGONIST->TARGET
Structure of ALTINICLINE
AGONIST -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_243] [2_243] [3_243] S-PALMITOYL CYSTEINE 08WQ73S7SV
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
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