Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H7NS |
| Molecular Weight | 185.245 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
S=C=NC1=C2C=CC=CC2=CC=C1
InChI
InChIKey=JBDOSUUXMYMWQH-UHFFFAOYSA-N
InChI=1S/C11H7NS/c13-8-12-11-7-3-5-9-4-1-2-6-10(9)11/h1-7H
| Molecular Formula | C11H7NS |
| Molecular Weight | 185.245 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes. | 2009-04 |
|
| Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry. | 2008-12 |
|
| Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease. | 2008-12 |
|
| Urinary metabolic fingerprinting for alpha-naphthylisothiocyanate-induced intrahepatic cholestasis in rats using Fourier transform-ion cyclotron resonance mass spectrometry. | 2008-10 |
|
| Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway. | 2008-08-20 |
|
| A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats. | 2008-08-19 |
|
| Validation of putative genomic biomarkers of nephrotoxicity in rats. | 2008-04-18 |
|
| Protective response of the Ah receptor to ANIT-induced biliary epithelial cell toxicity in see-through medaka. | 2008-04 |
|
| Integration of clinical chemistry, expression, and metabolite data leads to better toxicological class separation. | 2008-04 |
|
| [Role of early growth response factor-1 signal pathway in acute intrahepatic cholestatic hepatic injury in rats]. | 2008-03 |
|
| Hepatoprotective effect of Hypericum japonicum extract and its fractions. | 2008-02-28 |
|
| Piecewise multivariate modelling of sequential metabolic profiling data. | 2008-02-19 |
|
| Seizure susceptibility alteration following reversible cholestasis in mice: Modulation by opioids and nitric oxide. | 2008-02-12 |
|
| Integrative top-down system metabolic modeling in experimental disease states via data-driven Bayesian methods. | 2008-02 |
|
| Non invasive high resolution in vivo imaging of alpha-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka. | 2008-01-20 |
|
| A CD133-expressing murine liver oval cell population with bilineage potential. | 2007-10 |
|
| Determination and kinetics of producing glucosamine using fungi. | 2007-09-21 |
|
| Acute hepatotoxicity: a predictive model based on focused illumina microarrays. | 2007-09 |
|
| Uniform procedure of (1)H NMR analysis of rat urine and toxicometabonomics Part II: comparison of NMR profiles for classification of hepatotoxicity. | 2007-07 |
|
| Bone marrow fails to differentiate into liver epithelium during murine development and regeneration. | 2007-05 |
|
| Melatonin attenuates disruption of serum cholesterol status in rats with a single alpha-naphthylisothiocyanate treatment. | 2007-03 |
|
| Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. | 2007-03 |
|
| Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats. | 2007-02-12 |
|
| Protective effect of glycyrrhizin and matrine on acute vanishing bile duct syndrome induced by alpha-naphthylisothiocyanate in rats. | 2007-02 |
|
| Protective effect of glycyrrhizin, glycyrrhetic acid and matrine on acute cholestasis induced by alpha-naphthyl isothiocyanate in rats. | 2007-02 |
|
| Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue. | 2007-01 |
|
| Investigation of the hepatotoxicity profile of chemical entities using Liverbeads and WIF-B9 in vitro models. | 2006-09 |
|
| The potential risks of nanomaterials: a review carried out for ECETOC. | 2006-08-14 |
|
| ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18. | 2006-08 |
|
| Heterogeneity of the intrahepatic biliary epithelium. | 2006-06-14 |
|
| alpha-Tocopherol protects against alpha-naphthylisothiocyanate-induced hepatotoxicity in rats less effectively than melatonin. | 2006-06-10 |
|
| Lack of evidence that bone marrow cells contribute to cholangiocyte repopulation during experimental cholestatic ductal hyperplasia. | 2006-05 |
|
| Analysis of kanamycin A in human plasma and in oral dosage form by derivatization with 1-naphthyl isothiocyanate and high-performance liquid chromatography. | 2006-03 |
|
| Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system. | 2006 |
|
| Liquid chromatography-mass spectrometric analysis of urinary metabolites and their pattern recognition for the prediction of drug-induced hepatotoxicity. | 2005-12 |
|
| Pharmacokinetics of alpha-naphthyl isothiocyanate in rats. | 2005-11 |
|
| NMR spectroscopic-based metabonomic investigation on the acute biochemical effects induced by Ce(NO3)3 in rats. | 2005-11 |
|
| Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy. | 2005-10 |
|
| Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. | 2005-09-29 |
|
| Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products. | 2005-08 |
|
| Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation. | 2005-07-21 |
|
| Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice. | 2005-07-01 |
|
| Biliary excretion of taurocholate, organic anions and vinblastine in rats with alpha-naphthylisothiocyanate-induced cholestasis. | 2005-07 |
|
| Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats. | 2005-06-20 |
|
| Comparison of metabolic profiles from serum from hepatotoxin-treated rats by nuclear-magnetic-resonance-spectroscopy-based metabonomic analysis. | 2005-05-01 |
|
| Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by alpha-naphthylisothiocyanate. | 2005-05 |
|
| Identification of 4-methylspinaceamine--a Pictet-Spengler condensation reaction product of histamine with acetaldehyde--in human urine. | 2005-01-28 |
|
| In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid. | 2005 |
|
| Lack of benefit of ursodeoxycholic acid in drug-induced cholestasis in the rat. | 1992-05 |
|
| Relationship between alpha-naphthylisothiocyanate-induced liver injury and elevations in hepatic non-protein sulfhydryl content. | 1991-08-22 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:53:27 GMT 2025
by
admin
on
Mon Mar 31 18:53:27 GMT 2025
|
| Record UNII |
HG44814A3V
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
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Systematic Name | English | ||
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Preferred Name | English | ||
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Code | English | ||
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| Code System | Code | Type | Description | ||
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208-990-8
Created by
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551-06-4
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HG44814A3V
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89741
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11080
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DTXSID8025703
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m7763
Created by
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PRIMARY | Merck Index | ||
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35455
Created by
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1-Naphthylisothiocyanate
Created by
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PRIMARY |