Dibotatug

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:12:56 GMT 2025` Edited by `admin` on `Wed Apr 02 11:12:56 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	HBU6X8D6VB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Dibotatug

Official Name

English

DR-01

Preferred Name

English

Immunoglobulin G1, anti-(human/Macaca fascicularis/Macaca mulatta killer cell lectin-like receptor KLRD1) (human monoclonal DR-01 ?1-chain), disulfide with human monoclonal DR-01 ?-chain, dimer

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens KLRD1 (killer cell lectinlike receptor D1, CD94)], Homo sapiens monoclonal antibody

Common Name

English

dibotatug [INN]

Common Name

English

H-gamma1 heavy chain Homo sapiens (1-450) [VH (Homo sapiens IGHV3-21*01 (95.9%) -(IGHD) -IGHJ6*04 (94.4%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (217) (121-218), hinge

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C190114

Created by admin on Wed Apr 02 11:12:56 GMT 2025 , Edited by admin on Wed Apr 02 11:12:56 GMT 2025

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SMS_ID

300000049414

Created by admin on Wed Apr 02 11:12:56 GMT 2025 , Edited by admin on Wed Apr 02 11:12:56 GMT 2025

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INN

12902

Created by admin on Wed Apr 02 11:12:56 GMT 2025 , Edited by admin on Wed Apr 02 11:12:56 GMT 2025

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CAS

2842038-48-4

Created by admin on Wed Apr 02 11:12:56 GMT 2025 , Edited by admin on Wed Apr 02 11:12:56 GMT 2025

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FDA UNII

HBU6X8D6VB

Created by admin on Wed Apr 02 11:12:56 GMT 2025 , Edited by admin on Wed Apr 02 11:12:56 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_214
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN, AFUCOSYLATED

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					HBU6X8D6VB

Dibotatug

ACTIVE MOIETY

Comments:

DR-01 is a non-fucosylated human IgG1 monoclonal antibody directed against CD94 (Cluster of Differentiation 94), a receptor expressed predominantly on the surface of natural killer (NK) cells and terminally differentiated effector CD8+ cells. These cells represent the pathological population in large granular lymphocytic (LGL) leukemia and cytotoxic lymphomas. CD94 is not generally expressed on other immune cells or non-immune cells.

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL