U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:53:24 GMT 2023
Edited
by admin
on Sat Dec 16 18:53:24 GMT 2023
Source Materials Class ORGANISM
Source Materials Type ALLOGENIC HUMAN
Source Materials Parent
Part UMBILICAL CORD
Fraction Material Type CELL
Fraction Name Natural killer
Record UNII
HB2DF85W83
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Sitocabnagene Loxiveleucel
INN  
Official Name English
ALLOGENEIC NATURAL KILLER (NK) CELLS DERIVED FROM UMBILICAL CORD BLOOD, TRANSDUCED WITH A MOLONEY MURINE LEUKAEMIA VIRUS (MMLV)-BASED RETROVIRAL VECTOR ENCODING INDUCIBLE CASPASE-9 COMPRISING HUMAN CASPASE-9 FUSED TO A HUMAN FK506 BINDING PROTEIN VARIANT
Common Name English
SITOCABTAGENE LOXIVELEUCEL [USAN]
Common Name English
sitocabnagene loxiveleucel [INN]
Common Name English
Code System Code Type Description
FDA UNII
HB2DF85W83
Created by admin on Sat Dec 16 18:53:24 GMT 2023 , Edited by admin on Sat Dec 16 18:53:24 GMT 2023
PRIMARY
USAN
LM-222
Created by admin on Sat Dec 16 18:53:24 GMT 2023 , Edited by admin on Sat Dec 16 18:53:24 GMT 2023
PRIMARY
INN
11900
Created by admin on Sat Dec 16 18:53:24 GMT 2023 , Edited by admin on Sat Dec 16 18:53:24 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CULTURE ACTIVATOR HUMAN INTERLEUKIN-2 FNO32LO217
RETROVIRAL TRANSFECTION TRANSFECTION SITOCABNAGENE LOXIVELEUCEL VECTOR ULQ7T5U8MY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN HUMAN IL-15 HRJ300HC9W
INSERTED GENE EXPRESSION VECTOR SITOCABNAGENE LOXIVELEUCEL TRANSGENE INSERT NLV7KD79YL
VECTOR EXPRESSED PROTEIN SITOCABNAGENE LOXIVELEUCEL EXPRESSED INDUCIBLE CASPASE-9 COMPRISING HUMAN CASPASE-9 FUSED TO A HUMAN FK506 BINDING PROTEIN VARIANT (FKBP-F36V) 22AMU9W4UX
VECTOR EXPRESSED PROTEIN SITOCABNAGENE LOXIVELEUCEL EXPRESSED A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING CD19 FUSED TO CD28 AND CD3 ZETA SIGNALLING DOMAINS DR57VB3CAB
Name Property Type Amount Referenced Substance Defining Parameters References
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN NOT EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL