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Details

Stereochemistry ABSOLUTE
Molecular Formula C23H22FN7O3.H2O
Molecular Weight 481.4804
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMG-337 MONOHYDRATE

SMILES

C[C@]([H])(c1nnc2c(cc(cn12)-c3cnn(C)c3)F)n4ccc5c(cc(cn5)OCCOC)c4=O.O

InChI

InChIKey=FQOJZRILDACBLT-PFEQFJNWSA-N
InChI=1S/C23H22FN7O3.H2O/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16;/h4-5,8-14H,6-7H2,1-3H3;1H2/t14-;/m1./s1

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C23H22FN7O3
Molecular Weight 463.4652
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment:: http://www.amgenoncology-international.com/#/our-products/our-pipeline/

AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the cell surface enzyme called c-Met, which, when dysregulated, stimulates cancer cell scattering, invasion and protection from apoptosis. AMG 337, currently in Phase 2 development for the treatment of gastric and esophageal adenocarcinoma. In addition, recently was shown, that AMG 337 a promising and novel therapeutic strategy for targeting hepatocellular carcinomas with a dependence on HGF/MET signaling.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

150 mg, 200 mg and 300 mg orally daily. Additional 150 mg and 200 mg orally twice daily.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 13:17:25 UTC 2021
Edited
by admin
on Sat Jun 26 13:17:25 UTC 2021
Record UNII
H9QF5PWS0D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMG-337 MONOHYDRATE
Common Name English
1,6-NAPHTHYRIDIN-5(6H)-ONE, 6-((1R)-1-(8-FLUORO-6-(1-METHYL-1H-PYRAZOL-4-YL)-1,2,4-TRIAZOLO(4,3-A)PYRIDIN-3-YL)ETHYL)-3-(2-METHOXYETHOXY)-, HYDRATE (1:1)
Systematic Name English
Code System Code Type Description
FDA UNII
H9QF5PWS0D
Created by admin on Sat Jun 26 13:17:25 UTC 2021 , Edited by admin on Sat Jun 26 13:17:25 UTC 2021
PRIMARY
CAS
1643590-78-6
Created by admin on Sat Jun 26 13:17:25 UTC 2021 , Edited by admin on Sat Jun 26 13:17:25 UTC 2021
PRIMARY
PUBCHEM
122201344
Created by admin on Sat Jun 26 13:17:25 UTC 2021 , Edited by admin on Sat Jun 26 13:17:25 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE