U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 13:30:06 GMT 2023
Edited
by admin
on Sat Dec 16 13:30:06 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type INCOMPLETE
Record UNII
H9KH1GP3UU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CROVALIMAB
INN   USAN  
Official Name English
RG6107
Code English
Crovalimab [WHO-DD]
Common Name English
RO7112689
Code English
CROVALIMAB [JAN]
Common Name English
IMMUNOGLOBULIN G1, ANTI-(HUMAN COMPLEMENT C5)(HUMANIZED RO7112689 HEAVY CHAIN), DISULFIDE WITH HUMANIZED RO7112689 LIGHT CHAIN, DIMER
Common Name English
IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS C5 (COMPLEMENT 5)), MONOCLONAL ANTIBODYGAMMA1 HEAVY CHAIN (1-451) (VH (VICUGNA PACOS IGHV3S1*01 (70.4%)/HOMO SAPIENS IGHV3-66*01 (69.4%)-(IGHD)-HOMO SAPIENS IGHJ4*01 (100%)) (9.8.15) (1-123)-HOMO SAPIENS IGHG1*
Systematic Name English
CROVALIMAB [USAN]
Common Name English
COMPLEMENT C5 INHIBITORY HUMANIZED RECYCLING MONOCLONAL ANTIBODY (RG-6107 )
Common Name English
RO-7112689
Code English
crovalimab [INN]
Common Name English
SKY-59
Code English
SKY59
Code English
RG-6107
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 590717
Created by admin on Sat Dec 16 13:30:06 GMT 2023 , Edited by admin on Sat Dec 16 13:30:06 GMT 2023
Code System Code Type Description
FDA UNII
H9KH1GP3UU
Created by admin on Sat Dec 16 13:30:06 GMT 2023 , Edited by admin on Sat Dec 16 13:30:06 GMT 2023
PRIMARY
USAN
GH-174
Created by admin on Sat Dec 16 13:30:06 GMT 2023 , Edited by admin on Sat Dec 16 13:30:06 GMT 2023
PRIMARY
CAS
1917321-26-6
Created by admin on Sat Dec 16 13:30:06 GMT 2023 , Edited by admin on Sat Dec 16 13:30:06 GMT 2023
PRIMARY
NCI_THESAURUS
C169867
Created by admin on Sat Dec 16 13:30:06 GMT 2023 , Edited by admin on Sat Dec 16 13:30:06 GMT 2023
PRIMARY
INN
10882
Created by admin on Sat Dec 16 13:30:06 GMT 2023 , Edited by admin on Sat Dec 16 13:30:06 GMT 2023
PRIMARY
From To
1_22 1_97
2_22 2_97
3_23 3_88
3_137 3_197
4_137 4_197
4_23 4_88
1_150 1_206
1_226 3_217
1_232 2_232
1_235 2_235
1_267 1_327
1_373 1_431
2_150 2_206
2_226 4_217
2_267 2_327
2_373 2_431
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_303
N 2_303
Related Record Type Details
TARGET -> INHIBITOR
pH 7.4
Kd
TARGET -> INHIBITOR
pH 6.0
Kd
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL