Crovalimab

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:48:51 GMT 2025` Edited by `admin` on `Tue Apr 01 20:48:51 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	INCOMPLETE
Record UNII	H9KH1GP3UU
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

Crovalimab

Official Name

English

RG-6107

Preferred Name

English

RG6107

Code

English

Crovalimab [WHO-DD]

Common Name

English

RO7112689

Code

English

Crovalimab [JAN]

Common Name

English

Immunoglobulin G1, anti-(human complement C5)(humanized RO7112689 heavy chain), disulfide with humanized RO7112689 light chain, dimer

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens C5 (complement 5)], monoclonal antibody; gamma1 heavy chain (1-451) [VH (Vicugna pacos IGHV3S1*01 (70.4%)/Homo sapiens IGHV3-66*01 (69.4%) -(IGHD)-Homo sapiens IGHJ4*01 (100%)) [9.8.15] (1-123) -Homo sapiens IG

Common Name

English

CROVALIMAB [USAN]

Common Name

English

COMPLEMENT C5 INHIBITORY HUMANIZED RECYCLING MONOCLONAL ANTIBODY (RG-6107 )

Common Name

English

RO-7112689

Code

English

crovalimab [INN]

Common Name

English

SKY-59

Code

English

SKY59

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

590717

Created by admin on Tue Apr 01 20:48:51 GMT 2025 , Edited by admin on Tue Apr 01 20:48:51 GMT 2025

Code System Code Type Description

FDA UNII

H9KH1GP3UU

Created by admin on Tue Apr 01 20:48:51 GMT 2025 , Edited by admin on Tue Apr 01 20:48:51 GMT 2025

PRIMARY

USAN

GH-174

Created by admin on Tue Apr 01 20:48:51 GMT 2025 , Edited by admin on Tue Apr 01 20:48:51 GMT 2025

PRIMARY

DAILYMED

H9KH1GP3UU

Created by admin on Tue Apr 01 20:48:51 GMT 2025 , Edited by admin on Tue Apr 01 20:48:51 GMT 2025

PRIMARY

CAS

1917321-26-6

Created by admin on Tue Apr 01 20:48:51 GMT 2025 , Edited by admin on Tue Apr 01 20:48:51 GMT 2025

PRIMARY

NCI_THESAURUS

C169867

Created by admin on Tue Apr 01 20:48:51 GMT 2025 , Edited by admin on Tue Apr 01 20:48:51 GMT 2025

PRIMARY

SMS_ID

100000183536

Created by admin on Tue Apr 01 20:48:51 GMT 2025 , Edited by admin on Tue Apr 01 20:48:51 GMT 2025

PRIMARY

INN

10882

Created by admin on Tue Apr 01 20:48:51 GMT 2025 , Edited by admin on Tue Apr 01 20:48:51 GMT 2025

PRIMARY

From	To
1_22	1_97
2_22	2_97
3_23	3_88
3_137	3_197
4_137	4_197
4_23	4_88
1_150	1_206
1_226	3_217
1_232	2_232
1_235	2_235
1_267	1_327
1_373	1_431
2_150	2_206
2_226	4_217
2_267	2_327
2_373	2_431

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_303
N	2_303

Related Record Type Details

Crovalimab-AKKZ

SUB_CONCEPT->SUBSTANCE

Amount:


					7A6G4V3R84

TARGET -> INHIBITOR

Comments:

pH 7.4

Qualification:

Kd

Amount:


					7A6G4V3R84

TARGET -> INHIBITOR

Comments:

pH 6.0

Qualification:

Kd

Amount:

Related Record Type Details


					H9KH1GP3UU

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL