Ribrecabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 20:01:50 UTC 2023` Edited by `admin` on `Sat Dec 16 20:01:50 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	WHOLE
Fraction Material Type	CELL
Fraction Name	T cells enriched for CD3 and activated by culture in bags coated with anti-CD3 antibody and recombinant human fibronectin fragment
Record UNII	H9BE3VZU4A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ribrecabtagene Autoleucel

Official Name

English

Autologous T lymphocytes obtained from peripheral blood by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting the B-cell maturation antigen (BCMA). The expressed tran

Common Name

English

ribrecabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

H9BE3VZU4A

Created by admin on Sat Dec 16 20:01:50 UTC 2023 , Edited by admin on Sat Dec 16 20:01:50 UTC 2023

PRIMARY

INN

12662

Created by admin on Sat Dec 16 20:01:50 UTC 2023 , Edited by admin on Sat Dec 16 20:01:50 UTC 2023

PRIMARY

Related Record Type Details


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					H9BE3VZU4A

Ribrecabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION	GENE MODIFICATION		Ribrecabtagene autoleucel lentiviral vector	DES7CW6LMB
CULTURE	EXPANSION	BIOLOGICAL		HUMAN INTERLEUKIN-2	FNO32LO217

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Ribrecabtagene autoleucel expressed chimeric antigen receptor (CAR) targeting the BCMA antigen	387PUP6BJQ
INSERTED GENE EXPRESSION VECTOR					Ribrecabtagene autoleucel transgene insert encoding anti-BCMA chimeric antigen receptor (CAR)	GU45A22HLZ