U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 20:01:50 GMT 2023
Edited
by admin
on Sat Dec 16 20:01:50 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part WHOLE
Fraction Material Type CELL
Fraction Name T cells enriched for CD3 and activated by culture in bags coated with anti-CD3 antibody and recombinant human fibronectin fragment
Record UNII
H9BE3VZU4A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Ribrecabtagene Autoleucel
INN  
Official Name English
Autologous T lymphocytes obtained from peripheral blood by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting the B-cell maturation antigen (BCMA). The expressed tran
Common Name English
ribrecabtagene autoleucel [INN]
Common Name English
Code System Code Type Description
FDA UNII
H9BE3VZU4A
Created by admin on Sat Dec 16 20:01:50 GMT 2023 , Edited by admin on Sat Dec 16 20:01:50 GMT 2023
PRIMARY
INN
12662
Created by admin on Sat Dec 16 20:01:50 GMT 2023 , Edited by admin on Sat Dec 16 20:01:50 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
LENTIVIRAL TRANSFECTION TRANSFECTION GENE MODIFICATION Ribrecabtagene autoleucel lentiviral vector DES7CW6LMB
CULTURE EXPANSION BIOLOGICAL HUMAN INTERLEUKIN-2 FNO32LO217

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN Ribrecabtagene autoleucel expressed chimeric antigen receptor (CAR) targeting the BCMA antigen 387PUP6BJQ
INSERTED GENE EXPRESSION VECTOR Ribrecabtagene autoleucel transgene insert encoding anti-BCMA chimeric antigen receptor (CAR) GU45A22HLZ