DIPHENIDINE

C(C(N1CCCCC1)C2=CC=CC=C2)C3=CC=CC=C3

InChIKey=JQWJJJYHVHNXJH-UHFFFAOYSA-N

InChI=1S/C19H23N/c1-4-10-17(11-5-1)16-19(18-12-6-2-7-13-18)20-14-8-3-9-15-20/h1-2,4-7,10-13,19H,3,8-9,14-16H2

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Targets

Primary Target	Pharmacology	Potency
Glutamate [NMDA] receptor 125 Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7504360	Antagonist 2778
Norepinephrine transporter 191 Target ID: CHEMBL222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29225192	Inhibitor 8297	3.3 µM [IC50]
Dopamine transporter 180 Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29225192	Inhibitor 8297	3.4 µM [IC50]
Alpha-1A adrenergic receptor 19 Target ID: P35348\|\|\|B0ZBD9\|\|\|Q6RUJ8 Gene ID: 148.0 Gene Symbol: ADRA1A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29225192	Binding Agent 1064	11.0 µM [Ki]
Alpha-2A adrenergic receptor 26 Target ID: P08913 Gene ID: 150.0 Gene Symbol: ADRA2A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29225192	Binding Agent 1064	4.4 µM [Ki]
5-hydroxytryptamine receptor 1A 54 Target ID: P08908 Gene ID: 3350.0 Gene Symbol: HTR1A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29225192	Binding Agent 1064	11.0 µM [Ki]
5-hydroxytryptamine receptor 2A 69 Target ID: P28223 Gene ID: 3356.0 Gene Symbol: HTR2A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29225192	Binding Agent 1064	11.0 µM [Ki]

PubMed

Title	Date	PubMed
Are unconventional NMDA receptors involved in slowly adapting type I mechanoreceptor responses?	2005	15908129
NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds.	2009 May 1	19345586

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:21:42 UTC 2023` Edited by `admin` on `Sat Dec 16 11:21:42 UTC 2023`
Record UNII	H8Q4VPL82Y
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

DIPHENIDINE

Common Name

English

1-(1,2-DIPHENYLETHYL)PIPERIDINE

Systematic Name

English

PIPERIDINE, 1-(1,2-DIPHENYLETHYL)-

Systematic Name

English

J2.366.921H

Code

English

Classification Tree Code System Code

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