Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H11Cl3O2 |
Molecular Weight | 317.595 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(C=C1)C(C2=CC=C(O)C=C2)C(Cl)(Cl)Cl
InChI
InChIKey=IUGDILGOLSSKNE-UHFFFAOYSA-N
InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H
Molecular Formula | C14H11Cl3O2 |
Molecular Weight | 317.595 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
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Estrogen directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons. | 1999 Nov |
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Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. | 2000 Apr |
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Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. | 2000 Oct |
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Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements. | 2001 Jul |
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Actions of the endocrine disruptor methoxychlor and its estrogenic metabolite on in vitro embryonic rat seminiferous cord formation and perinatal testis growth. | 2001 May-Jun |
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Development of two androgen receptor assays using adenoviral transduction of MMTV-luc reporter and/or hAR for endocrine screening. | 2002 Mar |
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Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeys. | 2003 Jul |
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Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 Oct |
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Enantioselective recognition of mono-demethylated methoxychlor metabolites by the estrogen receptor. | 2004 Feb |
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Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. | 2004 Jan |
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Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: methoxychlor by human hepatic UDP-glucuronosyl transferases. | 2004 Jul |
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Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds. | 2006 Feb |
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Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes. | 2006 Jun |
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The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro. | 2006 Nov |
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Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
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Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. | 2010 Mar 15 |
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Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites. | 2011 Apr |
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Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. | 2011 Jan |
|
Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. | 2013 Jun 17 |
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Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER-CXCL12-CXCR4 signaling axis. | 2013 Sep |
|
Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on human and rat 17α-hydroxylase/17,20-lyase activity. | 2014 Mar 21 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 00:46:13 UTC 2023
by
admin
on
Sat Dec 16 00:46:13 UTC 2023
|
Record UNII |
H58165YO91
|
Record Status |
Validated (UNII)
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Record Version |
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-
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2971-36-0
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HPTE
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C404910
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SUB32996
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100000126263
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7045
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DTXSID8022325
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76302
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34025
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H58165YO91
Created by
admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
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