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Details

Stereochemistry ACHIRAL
Molecular Formula C14H11Cl3O2
Molecular Weight 317.595
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROXYCHLOR

SMILES

OC1=CC=C(C=C1)C(C2=CC=C(O)C=C2)C(Cl)(Cl)Cl

InChI

InChIKey=IUGDILGOLSSKNE-UHFFFAOYSA-N
InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H

HIDE SMILES / InChI

Molecular Formula C14H11Cl3O2
Molecular Weight 317.595
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme.
2000 Mar
Differential estrogen receptor binding of estrogenic substances: a species comparison.
2000 Nov 15
Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice.
2001 Sep
Embryonic co-exposure to methoxychlor and Clophen A50 alters sexual behavior in adult male quail.
2005 Apr
A comparison of in vitro and in vivo EDSTAC test battery results for detecting antiandrogenic activity.
2005 Jan 1
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways.
2006 Sep
Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells.
2008 Jan
Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.
2008 May
In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project.
2010 Apr
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.
2010 Mar 15
Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites.
2011 Apr
Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes.
2011 Apr
Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles.
2011 Jan
The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production.
2011 Jul
Estrogen receptor alpha overexpressing mouse antral follicles are sensitive to atresia induced by methoxychlor and its metabolites.
2012 Jun
Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER-CXCL12-CXCR4 signaling axis.
2013 Sep
Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice.
2015 Apr
Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro.
2015 Jan
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 17 11:01:48 UTC 2022
Edited
by admin
on Sat Dec 17 11:01:48 UTC 2022
Record UNII
H58165YO91
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDROXYCHLOR
Common Name English
1,1,1-TRICHLORO-2,2-BIS(4-HYDROXYPHENYL)ETHANE
Systematic Name English
P,P'-HO-DDT
Common Name English
PHENOL, 4,4'- (2,2,2-TRICHLOROETHYLIDENE)BIS-
Systematic Name English
4,4'-(2,2,2-TRICHLOROETHANE-1,1-DIYL)DIPHENOL
Systematic Name English
.ALPHA.,.ALPHA.-BIS(4-HYDROXYPHENYL)-.BETA.,.BETA.,.BETA.-TRICHLOROETHANE
Systematic Name English
1,1,1-TRICHLORO-2,2-BIS(P-HYDROXYPHENYL)ETHANE
Common Name English
HPTE
Common Name English
2,2-BIS(4-HYDROXYPHENYL)-1,1,1-TRICHLOROETHANE
Systematic Name English
BISDEMETHYLMETHOXYCHLOR
Common Name English
1,1-BIS(P-HYDROXYPHENYL)-2,2,2-TRICHLOROETHANE
Common Name English
1,1-BIS(4-HYDROXYPHENYL)-2,2,2-TRICHLOROETHANE
Systematic Name English
NSC-7045
Code English
PHENOL, 4,4'-(2,2,2-TRICHLOROETHYLIDENE)DI-
Systematic Name English
4,4'-DIHYDROXYDIPHENYLTRICHLOROETHANE
Common Name English
Code System Code Type Description
CAS
2971-36-0
Created by admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
PRIMARY
WIKIPEDIA
HPTE
Created by admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
PRIMARY
MESH
C404910
Created by admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
PRIMARY
EVMPD
SUB32996
Created by admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
PRIMARY
NSC
7045
Created by admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
PRIMARY
EPA CompTox
DTXSID8022325
Created by admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
PRIMARY
PUBCHEM
76302
Created by admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
PRIMARY
CHEBI
34025
Created by admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
PRIMARY
FDA UNII
H58165YO91
Created by admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
PRIMARY
Related Record Type Details
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