Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H11Cl3O2 |
Molecular Weight | 317.595 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(C=C1)C(C2=CC=C(O)C=C2)C(Cl)(Cl)Cl
InChI
InChIKey=IUGDILGOLSSKNE-UHFFFAOYSA-N
InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H
Molecular Formula | C14H11Cl3O2 |
Molecular Weight | 317.595 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme. | 2000 Mar |
|
Differential estrogen receptor binding of estrogenic substances: a species comparison. | 2000 Nov 15 |
|
Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice. | 2001 Sep |
|
Embryonic co-exposure to methoxychlor and Clophen A50 alters sexual behavior in adult male quail. | 2005 Apr |
|
A comparison of in vitro and in vivo EDSTAC test battery results for detecting antiandrogenic activity. | 2005 Jan 1 |
|
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways. | 2006 Sep |
|
Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells. | 2008 Jan |
|
Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. | 2008 May |
|
In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. | 2010 Apr |
|
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. | 2010 Mar 15 |
|
Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites. | 2011 Apr |
|
Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes. | 2011 Apr |
|
Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. | 2011 Jan |
|
The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production. | 2011 Jul |
|
Estrogen receptor alpha overexpressing mouse antral follicles are sensitive to atresia induced by methoxychlor and its metabolites. | 2012 Jun |
|
Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER-CXCL12-CXCR4 signaling axis. | 2013 Sep |
|
Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice. | 2015 Apr |
|
Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro. | 2015 Jan |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 17 11:01:48 UTC 2022
by
admin
on
Sat Dec 17 11:01:48 UTC 2022
|
Record UNII |
H58165YO91
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
2971-36-0
Created by
admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
|
PRIMARY | |||
|
HPTE
Created by
admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
|
PRIMARY | |||
|
C404910
Created by
admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
|
PRIMARY | |||
|
SUB32996
Created by
admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
|
PRIMARY | |||
|
7045
Created by
admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
|
PRIMARY | |||
|
DTXSID8022325
Created by
admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
|
PRIMARY | |||
|
76302
Created by
admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
|
PRIMARY | |||
|
34025
Created by
admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
|
PRIMARY | |||
|
H58165YO91
Created by
admin on Sat Dec 17 11:01:48 UTC 2022 , Edited by admin on Sat Dec 17 11:01:48 UTC 2022
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> METABOLITE |