HYDROXYCHLOR

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H11Cl3O2
Molecular Weight	317.595
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC=C(C=C1)C(C2=CC=C(O)C=C2)C(Cl)(Cl)Cl

InChI

InChIKey=IUGDILGOLSSKNE-UHFFFAOYSA-N

InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H

HIDE SMILES / InChI

Molecular Formula	C14H11Cl3O2
Molecular Weight	317.595
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme.	2000 Mar	10684797
Differential estrogen receptor binding of estrogenic substances: a species comparison.	2000 Nov 15	11162928
Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice.	2001 Sep	11509743
Embryonic co-exposure to methoxychlor and Clophen A50 alters sexual behavior in adult male quail.	2005 Apr	15526189
A comparison of in vitro and in vivo EDSTAC test battery results for detecting antiandrogenic activity.	2005 Jan 1	15589981
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways.	2006 Sep	16760418
Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells.	2008 Jan	17949972
Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.	2008 May	18400491
In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project.	2010 Apr	20368123
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.	2010 Mar 15	20143881
Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites.	2011 Apr	21252393
Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes.	2011 Apr	20522127
Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles.	2011 Jan	20826375
The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production.	2011 Jul	21664964
Estrogen receptor alpha overexpressing mouse antral follicles are sensitive to atresia induced by methoxychlor and its metabolites.	2012 Jun	22306526
Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER-CXCL12-CXCR4 signaling axis.	2013 Sep	22549810
Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice.	2015 Apr	25575267
Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro.	2015 Jan	25549949

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 17 11:01:48 UTC 2022` Edited by `admin` on `Sat Dec 17 11:01:48 UTC 2022`
Record UNII	H58165YO91
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HYDROXYCHLOR

Common Name

English

1,1,1-TRICHLORO-2,2-BIS(4-HYDROXYPHENYL)ETHANE

Systematic Name

English

P,P'-HO-DDT

Common Name

English

PHENOL, 4,4'- (2,2,2-TRICHLOROETHYLIDENE)BIS-

Systematic Name

English

4,4'-(2,2,2-TRICHLOROETHANE-1,1-DIYL)DIPHENOL

Systematic Name

English

.ALPHA.,.ALPHA.-BIS(4-HYDROXYPHENYL)-.BETA.,.BETA.,.BETA.-TRICHLOROETHANE

Systematic Name

English

1,1,1-TRICHLORO-2,2-BIS(P-HYDROXYPHENYL)ETHANE

Common Name

English

HPTE

Common Name

English

2,2-BIS(4-HYDROXYPHENYL)-1,1,1-TRICHLOROETHANE

Systematic Name

English

BISDEMETHYLMETHOXYCHLOR

Common Name

English

1,1-BIS(P-HYDROXYPHENYL)-2,2,2-TRICHLOROETHANE

Common Name

English

1,1-BIS(4-HYDROXYPHENYL)-2,2,2-TRICHLOROETHANE

Systematic Name

English

NSC-7045

Code

English

PHENOL, 4,4'-(2,2,2-TRICHLOROETHYLIDENE)DI-

Systematic Name

English

4,4'-DIHYDROXYDIPHENYLTRICHLOROETHANE

Common Name

English

Code System Code Type Description

CAS

2971-36-0