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Details

Stereochemistry ACHIRAL
Molecular Formula C14H11Cl3O2
Molecular Weight 317.595
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROXYCHLOR

SMILES

OC1=CC=C(C=C1)C(C2=CC=C(O)C=C2)C(Cl)(Cl)Cl

InChI

InChIKey=IUGDILGOLSSKNE-UHFFFAOYSA-N
InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H

HIDE SMILES / InChI

Molecular Formula C14H11Cl3O2
Molecular Weight 317.595
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Estrogen directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons.
1999 Nov
Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro.
2000 Apr
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.
2000 Oct
Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements.
2001 Jul
Actions of the endocrine disruptor methoxychlor and its estrogenic metabolite on in vitro embryonic rat seminiferous cord formation and perinatal testis growth.
2001 May-Jun
Development of two androgen receptor assays using adenoviral transduction of MMTV-luc reporter and/or hAR for endocrine screening.
2002 Mar
Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeys.
2003 Jul
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.
2003 Oct
Enantioselective recognition of mono-demethylated methoxychlor metabolites by the estrogen receptor.
2004 Feb
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.
2004 Jan
Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: methoxychlor by human hepatic UDP-glucuronosyl transferases.
2004 Jul
Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds.
2006 Feb
Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes.
2006 Jun
The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro.
2006 Nov
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.
2010 Mar 15
Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites.
2011 Apr
Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles.
2011 Jan
Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays.
2013 Jun 17
Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER-CXCL12-CXCR4 signaling axis.
2013 Sep
Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on human and rat 17α-hydroxylase/17,20-lyase activity.
2014 Mar 21
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 00:46:13 UTC 2023
Edited
by admin
on Sat Dec 16 00:46:13 UTC 2023
Record UNII
H58165YO91
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDROXYCHLOR
Common Name English
1,1,1-TRICHLORO-2,2-BIS(4-HYDROXYPHENYL)ETHANE
Systematic Name English
P,P'-HO-DDT
Common Name English
PHENOL, 4,4'- (2,2,2-TRICHLOROETHYLIDENE)BIS-
Systematic Name English
4,4'-(2,2,2-TRICHLOROETHANE-1,1-DIYL)DIPHENOL
Systematic Name English
.ALPHA.,.ALPHA.-BIS(4-HYDROXYPHENYL)-.BETA.,.BETA.,.BETA.-TRICHLOROETHANE
Systematic Name English
1,1,1-TRICHLORO-2,2-BIS(P-HYDROXYPHENYL)ETHANE
Common Name English
HPTE
Common Name English
2,2-BIS(4-HYDROXYPHENYL)-1,1,1-TRICHLOROETHANE
Systematic Name English
BISDEMETHYLMETHOXYCHLOR
Common Name English
1,1-BIS(P-HYDROXYPHENYL)-2,2,2-TRICHLOROETHANE
Common Name English
1,1-BIS(4-HYDROXYPHENYL)-2,2,2-TRICHLOROETHANE
Systematic Name English
NSC-7045
Code English
PHENOL, 4,4'-(2,2,2-TRICHLOROETHYLIDENE)DI-
Systematic Name English
4,4'-DIHYDROXYDIPHENYLTRICHLOROETHANE
Common Name English
Code System Code Type Description
CAS
2971-36-0
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
WIKIPEDIA
HPTE
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
MESH
C404910
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
EVMPD
SUB32996
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
SMS_ID
100000126263
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
NSC
7045
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
EPA CompTox
DTXSID8022325
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
PUBCHEM
76302
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
CHEBI
34025
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
FDA UNII
H58165YO91
Created by admin on Sat Dec 16 00:46:13 UTC 2023 , Edited by admin on Sat Dec 16 00:46:13 UTC 2023
PRIMARY
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