Enlonstobart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 16:54:35 GMT 2025` Edited by `admin` on `Wed Apr 02 16:54:35 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	H533QU433M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SG-001

Preferred Name

English

Enlonstobart

Official Name

English

Immunoglobulin G4 [221-proline], anti-(human programmed cell death protein 1) (human monoclonal SG001 ?4-chain), disulfide with human monoclonal SG001 ?-chain, dimer

Common Name

English

Immunoglobulin G4-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)], Homo sapiens monoclonal antibody

Common Name

English

enlonstobart [INN]

Common Name

English

SG001

Code

English

gamma4 heavy chain Homo sapiens (1-440) [VH(Homo sapiens IGHV3-33*01 (92.8%) -(IGHD)-IGHJ4*01 (100%), CDR-IMGT [8.8.6] (26-33.51-58.97-102)) (1-113) -Homo sapiens IGHG4*01, nG4m(a)CH2 L92, G4v5 h P10 (CH1 (114-211), hinge 1-12 S10>P (221) (212-223), CH2

Common Name

English

Enlonstobart [WHO-DD]

Common Name

English

Code System Code Type Description

INN

12413

Created by admin on Wed Apr 02 16:54:35 GMT 2025 , Edited by admin on Wed Apr 02 16:54:35 GMT 2025

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SMS_ID

300000050058

Created by admin on Wed Apr 02 16:54:35 GMT 2025 , Edited by admin on Wed Apr 02 16:54:35 GMT 2025

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CAS

2651230-53-2

Created by admin on Wed Apr 02 16:54:35 GMT 2025 , Edited by admin on Wed Apr 02 16:54:35 GMT 2025

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NCI_THESAURUS

C182009

Created by admin on Wed Apr 02 16:54:35 GMT 2025 , Edited by admin on Wed Apr 02 16:54:35 GMT 2025

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FDA UNII

H533QU433M

Created by admin on Wed Apr 02 16:54:35 GMT 2025 , Edited by admin on Wed Apr 02 16:54:35 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_127	4_214
2_140	2_196
2_254	2_314
1_127	3_214
2_360	2_418
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_140	1_196
1_219	2_219
1_222	2_222
1_254	1_314
1_360	1_418

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_290
N	2_290

Related Record Type Details


					938DNF64FO

PROGRAMMED CELL DEATH PROTEIN 1

TARGET->LIGAND

Amount:

Related Record Type Details


					H533QU433M

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_440] [2_440]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[3_1] [4_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL