AMIGLUMIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H36N2O4
Molecular Weight	440.575
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCN(CCCCC)C(=O)[C@@H](CCC(O)=O)NC(=O)C1=CC2=CC=CC=C2C=C1

InChI

InChIKey=LFMMKOQRKPJBIG-HSZRJFAPSA-N

InChI=1S/C26H36N2O4/c1-3-5-9-17-28(18-10-6-4-2)26(32)23(15-16-24(29)30)27-25(31)22-14-13-20-11-7-8-12-21(20)19-22/h7-8,11-14,19,23H,3-6,9-10,15-18H2,1-2H3,(H,27,31)(H,29,30)/t23-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C26H36N2O4
Molecular Weight	440.575
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://adisinsight.springer.com/drugs/800008170 | https://www.ncbi.nlm.nih.gov/pubmed/9832933

Amiglumide [CR 1795] is an amino acid derivative with cholecystokinin A antagonist activity. It has potential use for treating gastrointestinal disorders, pancreatitis and biliary dyskinesia. Amiglumide was developed in preclinical trials with Rottapharm in Italy.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
CR 2945: a novel CCKB receptor antagonist with anxiolytic-like activity.	1998 May	9832933
Effect of three nonpeptide cholecystokinin antagonists on human isolated gallbladder.	2001 Dec	11768273

Patents

Sample Use Guides

In Vivo Use Guide

Amiglumide [CR 1795] showed anxiolytic-like activity with a bell-shaped dose-response curve in the elevated zero-maze model in rats (0.1-10 mg/kg, orally and s.c.)

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:06:56 GMT 2023` Edited by `admin` on `Fri Dec 15 16:06:56 GMT 2023`
Record UNII	H48W1A97VB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMIGLUMIDE

Official Name

English

CR-1795

Code

English

(R)-4-(2-NAPHTHAMIDO)-N,N-DIPENTYLGLUTARAMIC ACID

Systematic Name

English

amiglumide [INN]

Common Name

English

CR1795

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29701