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Details

Stereochemistry ACHIRAL
Molecular Formula C8H12N4
Molecular Weight 164.208
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1-(2-PYRIMIDINYL)PIPERAZINE

SMILES

c1cnc(nc1)N2CCNCC2

InChI

InChIKey=MRBFGEHILMYPTF-UHFFFAOYSA-N
InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2

HIDE SMILES / InChI

Molecular Formula C8H12N4
Molecular Weight 164.208
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
A comparative multidose pharmacokinetic study of buspirone extended-release tablets with a reference immediate-release product.
2001 Aug
Pharmacokinetics and tolerability of buspirone during oral administration to children and adolescents with anxiety disorder and normal healthy adults.
2001 Dec
Pharmacokinetics of buspirone extended-release tablets: a single-dose study.
2001 Jul
Conformational analysis and pharmacophore design for selected 1-(2-pyrimidinyl)piperazine derivatives with sedative-hypnotic activity.
2001 Mar-Apr
The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-kappa B targeting in the alveolar epithelium.
2001 May
Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology.
2002
Factors explaining variance in perceived pain in women with fibromyalgia.
2002 Apr 25
Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats.
2002 Dec
Pharmacological properties and SAR of new 1,4-disubstituted piperazine derivatives with hypnotic-sedative activity.
2002 May
Science review: redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for hypoxia-inducible factor-1alpha.
2003 Feb
Human cytochromes mediating gepirone biotransformation at low substrate concentrations.
2003 Mar
The photocatalytic process as a tool to identify metabolitic products formed from dopant substances: the case of buspirone.
2004 Apr 1
Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP).
2005 Apr
Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes.
2005 Apr
Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes.
2005 Feb
Oral buspirone causes a shift in the dose-response curve between the elevated-plus maze and Vogel conflict tests in Long-Evans rats: relation of brain levels of buspirone and 1-PP to anxiolytic action.
2005 May
6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.
2007 Aug
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
2007 Sep 4
TRPV1: a target for next generation analgesics.
2008 Jun
Group 11 metal chemistry of a tetradentate ligand, phenylene-1,4-diaminotetra(phosphonite), p-C6H4[N{P(OC6H4OMe-o)2}2]2.
2009 Apr 20
Carboxy group derivatization for enhanced electron-transfer dissociation mass spectrometric analysis of phosphopeptides.
2009 Aug
Cyndi: a multi-objective evolution algorithm based method for bioactive molecular conformational generation.
2009 Mar 31
Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.
2010 Feb 1
Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-triazole) Mannich bases containing piperazine rings.
2010 May 12
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 07:56:04 UTC 2021
Edited
by admin
on Sat Jun 26 07:56:04 UTC 2021
Record UNII
H3B5B38F56
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1-(2-PYRIMIDINYL)PIPERAZINE
Systematic Name English
PYRIMIDINE, 2-(1-PIPERAZINYL)-
Systematic Name English
BUSPIRONE RELATED COMPOUND A [USP-RS]
Common Name English
2-(PIPERAZIN-1-YL)PYRIMIDINE
Systematic Name English
1-PYRIMIDINYLPIPERAZINE
Systematic Name English
BUSPIRONE RELATED COMPOUND A [USP]
Common Name English
1-(2-PYRIMIDINYL)-PIPERAZINE
Systematic Name English
Code System Code Type Description
ECHA (EC/EINECS)
244-135-5
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY
USP_CATALOG
1078573
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY USP-RS
PUBCHEM
88747
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY
FDA UNII
H3B5B38F56
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY
CAS
20980-22-7
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> METABOLITE ACTIVE
Related Record Type Details
PARENT -> IMPURITY
impurity detected at UV 240 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP