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Details

Stereochemistry ACHIRAL
Molecular Formula C8H12N4
Molecular Weight 164.208
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1-(2-PYRIMIDINYL)PIPERAZINE

SMILES

c1cnc(nc1)N2CCNCC2

InChI

InChIKey=MRBFGEHILMYPTF-UHFFFAOYSA-N
InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2

HIDE SMILES / InChI

Molecular Formula C8H12N4
Molecular Weight 164.208
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Pharmacokinetics and tolerability of buspirone during oral administration to children and adolescents with anxiety disorder and normal healthy adults.
2001 Dec
Pharmacokinetics of buspirone extended-release tablets: a single-dose study.
2001 Jul
Conformational analysis and pharmacophore design for selected 1-(2-pyrimidinyl)piperazine derivatives with sedative-hypnotic activity.
2001 Mar-Apr
The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-kappa B targeting in the alveolar epithelium.
2001 May
Effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose-induced hyperglycemia in mice.
2003 Dec
Human cytochromes mediating gepirone biotransformation at low substrate concentrations.
2003 Mar
1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat.
2004
Combination benefit of a pyrimidylpiperazine derivative (Y-40138) and methotrexate in arthritic rats.
2004 Aug 30
Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP).
2005 Apr
Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes.
2005 Apr
Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes.
2005 Feb
Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.
2007 Jul 26
Pharmacokinetics of 6-hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans.
2007 Oct
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
2007 Sep 4
TRPV1: a target for next generation analgesics.
2008 Jun
Mass spectrometry analysis of phosphopeptides after peptide carboxy group derivatization.
2008 Nov 1
Pharmacokinetic interaction between tandospirone and fluvoxamine in the rat contextual conditioned fear stress model and its functional consequence: Involvement of cytochrome P450 3A4.
2008 Oct
Group 11 metal chemistry of a tetradentate ligand, phenylene-1,4-diaminotetra(phosphonite), p-C6H4[N{P(OC6H4OMe-o)2}2]2.
2009 Apr 20
Carboxy group derivatization for enhanced electron-transfer dissociation mass spectrometric analysis of phosphopeptides.
2009 Aug
Cyndi: a multi-objective evolution algorithm based method for bioactive molecular conformational generation.
2009 Mar 31
Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification.
2009 Sep
A new strategy for antidepressant prescription.
2010
Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.
2010 Feb 1
Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-triazole) Mannich bases containing piperazine rings.
2010 May 12
Moving towards supraspinal TRPV1 receptors for chronic pain relief.
2010 Oct 11
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 07:56:04 UTC 2021
Edited
by admin
on Sat Jun 26 07:56:04 UTC 2021
Record UNII
H3B5B38F56
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1-(2-PYRIMIDINYL)PIPERAZINE
Systematic Name English
PYRIMIDINE, 2-(1-PIPERAZINYL)-
Systematic Name English
BUSPIRONE RELATED COMPOUND A [USP-RS]
Common Name English
2-(PIPERAZIN-1-YL)PYRIMIDINE
Systematic Name English
1-PYRIMIDINYLPIPERAZINE
Systematic Name English
BUSPIRONE RELATED COMPOUND A [USP]
Common Name English
1-(2-PYRIMIDINYL)-PIPERAZINE
Systematic Name English
Code System Code Type Description
ECHA (EC/EINECS)
244-135-5
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY
USP_CATALOG
1078573
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY USP-RS
PUBCHEM
88747
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY
FDA UNII
H3B5B38F56
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY
CAS
20980-22-7
Created by admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> METABOLITE ACTIVE
Related Record Type Details
PARENT -> IMPURITY
impurity detected at UV 240 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP