Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H12N4 |
| Molecular Weight | 164.208 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
c1cnc(nc1)N2CCNCC2
InChI
InChIKey=MRBFGEHILMYPTF-UHFFFAOYSA-N
InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2
| Molecular Formula | C8H12N4 |
| Molecular Weight | 164.208 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacokinetics and tolerability of buspirone during oral administration to children and adolescents with anxiety disorder and normal healthy adults. | 2001 Dec |
|
| Pharmacokinetics of buspirone extended-release tablets: a single-dose study. | 2001 Jul |
|
| Conformational analysis and pharmacophore design for selected 1-(2-pyrimidinyl)piperazine derivatives with sedative-hypnotic activity. | 2001 Mar-Apr |
|
| The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-kappa B targeting in the alveolar epithelium. | 2001 May |
|
| Effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose-induced hyperglycemia in mice. | 2003 Dec |
|
| Human cytochromes mediating gepirone biotransformation at low substrate concentrations. | 2003 Mar |
|
| 1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat. | 2004 |
|
| Combination benefit of a pyrimidylpiperazine derivative (Y-40138) and methotrexate in arthritic rats. | 2004 Aug 30 |
|
| Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP). | 2005 Apr |
|
| Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. | 2005 Apr |
|
| Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes. | 2005 Feb |
|
| Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. | 2007 Jul 26 |
|
| Pharmacokinetics of 6-hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans. | 2007 Oct |
|
| A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. | 2007 Sep 4 |
|
| TRPV1: a target for next generation analgesics. | 2008 Jun |
|
| Mass spectrometry analysis of phosphopeptides after peptide carboxy group derivatization. | 2008 Nov 1 |
|
| Pharmacokinetic interaction between tandospirone and fluvoxamine in the rat contextual conditioned fear stress model and its functional consequence: Involvement of cytochrome P450 3A4. | 2008 Oct |
|
| Group 11 metal chemistry of a tetradentate ligand, phenylene-1,4-diaminotetra(phosphonite), p-C6H4[N{P(OC6H4OMe-o)2}2]2. | 2009 Apr 20 |
|
| Carboxy group derivatization for enhanced electron-transfer dissociation mass spectrometric analysis of phosphopeptides. | 2009 Aug |
|
| Cyndi: a multi-objective evolution algorithm based method for bioactive molecular conformational generation. | 2009 Mar 31 |
|
| Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification. | 2009 Sep |
|
| A new strategy for antidepressant prescription. | 2010 |
|
| Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators. | 2010 Feb 1 |
|
| Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-triazole) Mannich bases containing piperazine rings. | 2010 May 12 |
|
| Moving towards supraspinal TRPV1 receptors for chronic pain relief. | 2010 Oct 11 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 07:56:04 UTC 2021
by
admin
on
Sat Jun 26 07:56:04 UTC 2021
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| Record UNII |
H3B5B38F56
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| Record Status |
Validated (UNII)
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| Record Version |
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244-135-5
Created by
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1078573
Created by
admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
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88747
Created by
admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
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H3B5B38F56
Created by
admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
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20980-22-7
Created by
admin on Sat Jun 26 07:56:04 UTC 2021 , Edited by admin on Sat Jun 26 07:56:04 UTC 2021
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> METABOLITE ACTIVE |
| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
impurity detected at UV 240 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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