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Details

Stereochemistry ACHIRAL
Molecular Formula C8H12N4
Molecular Weight 164.2077
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1-(2-PYRIMIDINYL)PIPERAZINE

SMILES

C1CN(CCN1)C2=NC=CC=N2

InChI

InChIKey=MRBFGEHILMYPTF-UHFFFAOYSA-N
InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2

HIDE SMILES / InChI

Molecular Formula C8H12N4
Molecular Weight 164.2077
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
A comparative multidose pharmacokinetic study of buspirone extended-release tablets with a reference immediate-release product.
2001 Aug
Pharmacokinetics of buspirone extended-release tablets: a single-dose study.
2001 Jul
Conformational analysis and pharmacophore design for selected 1-(2-pyrimidinyl)piperazine derivatives with sedative-hypnotic activity.
2001 Mar-Apr
Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology.
2002
Effects of the serotonergic anxiolytic buspirone on plasma glucose and glucose-induced hyperglycemia in mice.
2003 Dec
Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone.
2003 Dec
Science review: redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for hypoxia-inducible factor-1alpha.
2003 Feb
Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes.
2005 Apr
Pharmacokinetics of buspirone in autistic children.
2006 May
6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.
2007 Aug
Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.
2007 Jul 26
Pharmacokinetics of 6-hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans.
2007 Oct
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
2007 Sep 4
Mass spectrometry analysis of phosphopeptides after peptide carboxy group derivatization.
2008 Nov 1
Carboxy group derivatization for enhanced electron-transfer dissociation mass spectrometric analysis of phosphopeptides.
2009 Aug
Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification.
2009 Sep
Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-triazole) Mannich bases containing piperazine rings.
2010 May 12
Moving towards supraspinal TRPV1 receptors for chronic pain relief.
2010 Oct 11
Patents
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:01:59 UTC 2023
Edited
by admin
on Wed Jul 05 23:01:59 UTC 2023
Record UNII
H3B5B38F56
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1-(2-PYRIMIDINYL)PIPERAZINE
Systematic Name English
PYRIMIDINE, 2-(1-PIPERAZINYL)-
Systematic Name English
BUSPIRONE RELATED COMPOUND A [USP-RS]
Common Name English
2-(PIPERAZIN-1-YL)PYRIMIDINE
Systematic Name English
1-PYRIMIDINYLPIPERAZINE
Systematic Name English
BUSPIRONE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Common Name English
BUSPIRONE RELATED COMPOUND A [USP IMPURITY]
Common Name English
1-(2-PYRIMIDINYL)-PIPERAZINE
Systematic Name English
Code System Code Type Description
ECHA (EC/EINECS)
244-135-5
Created by admin on Wed Jul 05 23:01:59 UTC 2023 , Edited by admin on Wed Jul 05 23:01:59 UTC 2023
PRIMARY
RS_ITEM_NUM
1078573
Created by admin on Wed Jul 05 23:01:59 UTC 2023 , Edited by admin on Wed Jul 05 23:01:59 UTC 2023
PRIMARY
WIKIPEDIA
Pyrimidinylpiperazine
Created by admin on Wed Jul 05 23:01:59 UTC 2023 , Edited by admin on Wed Jul 05 23:01:59 UTC 2023
PRIMARY
PUBCHEM
88747
Created by admin on Wed Jul 05 23:01:59 UTC 2023 , Edited by admin on Wed Jul 05 23:01:59 UTC 2023
PRIMARY
FDA UNII
H3B5B38F56
Created by admin on Wed Jul 05 23:01:59 UTC 2023 , Edited by admin on Wed Jul 05 23:01:59 UTC 2023
PRIMARY
CAS
20980-22-7
Created by admin on Wed Jul 05 23:01:59 UTC 2023 , Edited by admin on Wed Jul 05 23:01:59 UTC 2023
PRIMARY
EPA CompTox
DTXSID00864967
Created by admin on Wed Jul 05 23:01:59 UTC 2023 , Edited by admin on Wed Jul 05 23:01:59 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> METABOLITE ACTIVE
Related Record Type Details
PARENT -> IMPURITY
impurity detected at UV 240 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP