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Details

Stereochemistry ACHIRAL
Molecular Formula C8H12N4
Molecular Weight 164.2077
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1-(2-PYRIMIDINYL)PIPERAZINE

SMILES

C1CN(CCN1)C2=NC=CC=N2

InChI

InChIKey=MRBFGEHILMYPTF-UHFFFAOYSA-N
InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2

HIDE SMILES / InChI

Molecular Formula C8H12N4
Molecular Weight 164.2077
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats.
2002 Dec
In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.
2003 Jan 10
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
2007 Sep 4
Mass spectrometry analysis of phosphopeptides after peptide carboxy group derivatization.
2008 Nov 1
Pharmacokinetic interaction between tandospirone and fluvoxamine in the rat contextual conditioned fear stress model and its functional consequence: Involvement of cytochrome P450 3A4.
2008 Oct
A new strategy for antidepressant prescription.
2010
Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-triazole) Mannich bases containing piperazine rings.
2010 May 12
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:00:26 GMT 2025
Edited
by admin
on Mon Mar 31 18:00:26 GMT 2025
Record UNII
H3B5B38F56
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1-PYRIMIDINYLPIPERAZINE
Preferred Name English
1-(2-PYRIMIDINYL)PIPERAZINE
Systematic Name English
PYRIMIDINE, 2-(1-PIPERAZINYL)-
Systematic Name English
2-PIPERAZINYLPYRIMIDINE
Common Name English
BUSPIRONE RELATED COMPOUND A [USP-RS]
Common Name English
2-(PIPERAZIN-1-YL)PYRIMIDINE
Systematic Name English
BUSPIRONE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Common Name English
BUSPIRONE RELATED COMPOUND A [USP IMPURITY]
Common Name English
1-PP
Common Name English
1-(2-PYRIMIDINYL)-PIPERAZINE
Systematic Name English
Code System Code Type Description
ECHA (EC/EINECS)
244-135-5
Created by admin on Mon Mar 31 18:00:26 GMT 2025 , Edited by admin on Mon Mar 31 18:00:26 GMT 2025
PRIMARY
RS_ITEM_NUM
1078573
Created by admin on Mon Mar 31 18:00:26 GMT 2025 , Edited by admin on Mon Mar 31 18:00:26 GMT 2025
PRIMARY
WIKIPEDIA
Pyrimidinylpiperazine
Created by admin on Mon Mar 31 18:00:26 GMT 2025 , Edited by admin on Mon Mar 31 18:00:26 GMT 2025
PRIMARY
PUBCHEM
88747
Created by admin on Mon Mar 31 18:00:26 GMT 2025 , Edited by admin on Mon Mar 31 18:00:26 GMT 2025
PRIMARY
FDA UNII
H3B5B38F56
Created by admin on Mon Mar 31 18:00:26 GMT 2025 , Edited by admin on Mon Mar 31 18:00:26 GMT 2025
PRIMARY
CAS
20980-22-7
Created by admin on Mon Mar 31 18:00:26 GMT 2025 , Edited by admin on Mon Mar 31 18:00:26 GMT 2025
PRIMARY
EPA CompTox
DTXSID00864967
Created by admin on Mon Mar 31 18:00:26 GMT 2025 , Edited by admin on Mon Mar 31 18:00:26 GMT 2025
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
At small doses, 1-PP (ED50 = 80 ?g/kg, i.v.) reversed the depressant effect of the ?2-adrenoceptor agonist, clonidine
SALT/SOLVATE -> PARENT
Related Record Type Details
PARENT -> METABOLITE ACTIVE
MAJOR
PARENT -> METABOLITE ACTIVE
PARENT -> METABOLITE ACTIVE
PARENT -> METABOLITE ACTIVE
Related Record Type Details
PARENT -> IMPURITY
impurity detected at UV 240 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP