P-NITROPHENYL-O-ETHYL ETHYLPHOSPHONATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14NO5P
Molecular Weight	259.1956
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of P-NITROPHENYL-O-ETHYL ETHYLPHOSPHONATE

Structure Search

SMILES

CCOP(=O)(CC)OC1=CC=C(C=C1)[N+]([O-])=O

InChI

InChIKey=XXUJMEYKYHETBZ-UHFFFAOYSA-N

InChI=1S/C10H14NO5P/c1-3-15-17(14,4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C10H14NO5P
Molecular Weight	259.1956
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://dxline.ru/drugs/armin
Curator's Comment: description was created based on several sources, including: http://www.medicinform.net/spravka/b1/b1_82.htm https://ru.wikipedia.org/wiki/%D0%90%D1%80%D0%BC%D0%B8%D0%BD

Armin is irreversible cholinesterase inhibitor. It acts considerably longer and stronger than reversible cholinesterase inhibitors. It is used for glaucoma treatment. Armin might be used in combination with other antiglaucoma drugs. Known adverse effects are: hypersalivation, sweating, dyspepsia, frequent urination, blurred vision, headache, dizziness, twitching of the tongue and skeletal muscles, nausea, vomiting.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Acetylcholinesterase 207 Target ID: CHEMBL220 Sources: https://www.ncbi.nlm.nih.gov/pubmed/674598 \| https://www.ncbi.nlm.nih.gov/pubmed/515367 \| https://www.ncbi.nlm.nih.gov/pubmed/19188831	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Glaucoma 57 Sources: http://www.medicinform.net/spravka/b1/b1_82.htm	Primary		Approved 8429	ARMIN Approved Use Armin is used for glaucoma treatment Launch Date 1999

PubMed

Title	Date	PubMed
[Clinical evaluation of armin].	1958 Jul-Aug	13593148
[Use of armin in glaucoma].	1960	13780545
[Effect of nibuphine, pilocarpine and armine on the size of the blind spot and angioscotoma in patients with primary glaucoma].	1971 Sep-Oct	5136387
[Treatment effectiveness in open-angle glaucoma using aqueous and prolonged-action armin solutions].	1980 May-Jun	7404931

Patents

Sample Use Guides

In Vivo Use Guide

1-2 drops 2-3 times per daily

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:20:00 GMT 2023` Edited by `admin` on `Fri Dec 15 17:20:00 GMT 2023`
Record UNII	H39MRI1X2O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

P-NITROPHENYL-O-ETHYL ETHYLPHOSPHONATE

Common Name

English

ARMIN

Brand Name

English

ETHYL 4-NITROPHENYL ETHYLPHOSPHONATE [JAN]

Common Name

English

ARMINE

Brand Name

English

Armine [WHO-DD]

Common Name

English

ETHYL 4-NITROPHENYL ETHYLPHOSPHONATE

Systematic Name

English

PHOSPHONIC ACID, P-ETHYL-, ETHYL 4-NITROPHENYL ESTER

Common Name

English

ARMEEN

Brand Name

English

Code System Code Type Description

WIKIPEDIA

Armine (chemical)