Adezkibart

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:52:30 GMT 2025` Edited by `admin` on `Wed Apr 02 09:52:30 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	H2X62LI6YV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Adezkibart

Official Name

English

Immunoglobulin G1 [236-phenylalanine,237-glutamic acid,333-serine], anti-(human fms-like receptor tyrosine kinase 3 ligand) (human monoclonal HZN-1116 ?1-chain), disulfide with human monoclonal HZN-1116 ?-chain, dimer

Preferred Name

English

adezkibart [INN]

Common Name

English

immunoglobulin G1-lambda2, anti-[Homo sapiens FLT3LG (fms related receptor tyrosine kinase 3 ligand)], Homo sapiens monoclonal antibody; H-gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV1-69*11 (89.7%) -(IGHD) -IGHJ5*01 (90.9%) L123>T (114

Common Name

English

Code System Code Type Description

CAS

2921564-55-6

Created by admin on Wed Apr 02 09:52:30 GMT 2025 , Edited by admin on Wed Apr 02 09:52:30 GMT 2025

PRIMARY

INN

13365

Created by admin on Wed Apr 02 09:52:30 GMT 2025 , Edited by admin on Wed Apr 02 09:52:30 GMT 2025

PRIMARY

FDA UNII

H2X62LI6YV

Created by admin on Wed Apr 02 09:52:30 GMT 2025 , Edited by admin on Wed Apr 02 09:52:30 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_146	2_202
2_222	4_216
2_263	2_323
1_146	1_202
2_369	2_427
3_22	3_91
3_139	3_198
4_22	4_91
4_139	4_198
1_222	3_216
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					6S1KJ9KP8S

FLT-3 LIGAND PROTEIN (MAMMALIAN GLYCOSYLATION)

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					H2X62LI6YV

Adezkibart

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS	K		LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL