METHOXPHENIDINE

COC1=C(C=CC=C1)C(CC2=CC=CC=C2)N3CCCCC3

InChIKey=QXXCUXIRBHSITD-UHFFFAOYSA-N

InChI=1S/C20H25NO/c1-22-20-13-7-6-12-18(20)19(21-14-8-3-9-15-21)16-17-10-4-2-5-11-17/h2,4-7,10-13,19H,3,8-9,14-16H2,1H3

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Targets

Primary Target	Pharmacology	Potency
Norepinephrine transporter 191 Target ID: CHEMBL222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29225192	Inhibitor 8297	7.8 µM [IC50]
Alpha-2a adrenergic receptor 63 Target ID: CHEMBL1867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29225192	Binding Agent 1064	2.6 µM [Ki]
Serotonin 2a (5-HT2a) receptor 231 Target ID: CHEMBL224 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29225192	Binding Agent 1064	8.2 µM [Ki]

PubMed

Title	Date	PubMed
Severe rhabdomyolysis and acute kidney injury associated with methoxphenidine.	2016 Jun	27007750
Methoxphenidine Use Disorder: First Case Notified to the French Addictovigilance Network.	2017 Jun	28272088
Effects of the new psychoactive substances diclofensine, diphenidine, and methoxphenidine on monoaminergic systems.	2018 Jan 15	29225192

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:18:33 UTC 2023` Edited by `admin` on `Sat Dec 16 11:18:33 UTC 2023`
Record UNII	H2W7A6GZGX
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

METHOXPHENIDINE

Common Name

English

2-MEO-DIPHENIDINE

Common Name

English

METHOXYDIPHENIDINE

Common Name

English

PIPERIDINE, 1-(1-(2-METHOXYPHENYL)-2-PHENYLETHYL)-, (±)-

Systematic Name

English

MXP

Common Name

English

PIPERIDINE, 1-(1-(2-METHOXYPHENYL)-2-PHENYLETHYL)-

Systematic Name

English

Classification Tree Code System Code

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