Details
Stereochemistry | ACHIRAL |
Molecular Formula | C8H18N2.O4S.Pt |
Molecular Weight | 433.389 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Pt++].[O-]S([O-])(=O)=O.NCC1(CN)CCCCC1
InChI
InChIKey=XASGSSXPZXRXFL-UHFFFAOYSA-L
InChI=1S/C8H18N2.H2O4S.Pt/c9-6-8(7-10)4-2-1-3-5-8;1-5(2,3)4;/h1-7,9-10H2;(H2,1,2,3,4);/q;;+2/p-2
Molecular Formula | O4S |
Molecular Weight | 96.063 |
Charge | -2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Pt |
Molecular Weight | 195.084 |
Charge | 2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C8H18N2 |
Molecular Weight | 142.2419 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Spiroplatin is a metal drug and analog of the second generation for cisplatin, developed for the treatment of cancer. Spiroplatin induces DNA cross-linking, thereby inhibiting DNA replication and the synthesis of RNA and protein. Initial clinical trials of spiroplatin have shown that it can cause less nausea and vomiting than cisplatin, and can be administered without hydration due to less renal toxicity. However, with increasing doses, the marginal toxicity was both renal and hematologic. In addition, spiroplatin was devoid of significant antitumor effects in advanced ovarian cancer, a disease in which some response can be expected. Based on these data, further development was discontinued.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1574259
30 mg/m2 every 3 weeks.
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:35:24 GMT 2023
by
admin
on
Fri Dec 15 15:35:24 GMT 2023
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Record UNII |
H2V318W7LE
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C1450
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C040757
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23725025
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H2V318W7LE
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C1234
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100000083809
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277-997-6
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T-26
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SUB10632MIG
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