U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 16:46:56 GMT 2023
Edited
by admin
on Sat Dec 16 16:46:56 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
H1V41MWX63
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Lusvertikimab
INN   USAN  
Official Name English
Immunoglobulin G4-kappa, anti-[Homo sapiens IL7R (interleukin 7 receptor, CD127, IL7RA)], humanized monoclonal antibody; gamma4 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-11*01 (90.8%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.15] (26-33.51-58.9
Common Name English
Immunoglobulin G4 [100-leucine,230-proline,447-proline], anti-(human interleukin-7 receptor subunit α) (human-Rattus norvegicus monoclonal OSE-127 γ4-chain), disulfide with [31-glutamine,53-threonine] human-Rattus norvegicus monoclonal OSE-127 κ-chain
Common Name English
LUSVERTIKIMAB [USAN]
Common Name English
lusvertikimab [INN]
Common Name English
OSE-127
Code English
Code System Code Type Description
CAS
2375835-91-7
Created by admin on Sat Dec 16 16:46:56 GMT 2023 , Edited by admin on Sat Dec 16 16:46:56 GMT 2023
PRIMARY
FDA UNII
H1V41MWX63
Created by admin on Sat Dec 16 16:46:56 GMT 2023 , Edited by admin on Sat Dec 16 16:46:56 GMT 2023
PRIMARY
NCI_THESAURUS
C179102
Created by admin on Sat Dec 16 16:46:56 GMT 2023 , Edited by admin on Sat Dec 16 16:46:56 GMT 2023
PRIMARY
USAN
KL-194
Created by admin on Sat Dec 16 16:46:56 GMT 2023 , Edited by admin on Sat Dec 16 16:46:56 GMT 2023
PRIMARY
INN
11533
Created by admin on Sat Dec 16 16:46:56 GMT 2023 , Edited by admin on Sat Dec 16 16:46:56 GMT 2023
PRIMARY INN
From To
4_134 4_194
4_23 4_88
3_134 3_194
3_23 3_88
2_369 2_427
2_263 2_323
2_149 2_205
2_136 4_214
2_22 2_96
1_369 1_427
1_263 1_323
1_231 2_231
1_228 2_228
1_149 1_205
1_136 3_214
1_22 1_96
Glycosylation Link Type Site
N 1_299
N 2_299
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL