U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 14:51:31 GMT 2023
Edited
by admin
on Sat Dec 16 14:51:31 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
H1396W7D1H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Favezelimab
INN   USAN  
Official Name English
MK-4280
Code English
MK4280
Code English
Favezelimab [WHO-DD]
Common Name English
MAVEZELIMAB
Common Name English
favezelimab [INN]
Common Name English
ANTI-LAG3 MONOCLONAL ANTIBODY MK-4280
Common Name English
Immunoglobulin G4 [227-proline], anti-(human lymphocyte activation gene-3) (human-Mus musculus monoclonal C88 γ4-chain), disulfide with human-Mus musculus monoclonal C88 κ-chain, dimer
Common Name English
Immunoglobulin G4-kappa, anti-[Homo sapiens LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223)], humanized monoclonal antibody; gamma4 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-58*01 (85.6%) -(IGHD) -IGHJ1*01 (91.7%)) [8.8.12] (1-
Common Name English
FAVEZELIMAB [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C134305
Created by admin on Sat Dec 16 14:51:31 GMT 2023 , Edited by admin on Sat Dec 16 14:51:31 GMT 2023
Code System Code Type Description
INN
11179
Created by admin on Sat Dec 16 14:51:31 GMT 2023 , Edited by admin on Sat Dec 16 14:51:31 GMT 2023
PRIMARY
FDA UNII
H1396W7D1H
Created by admin on Sat Dec 16 14:51:31 GMT 2023 , Edited by admin on Sat Dec 16 14:51:31 GMT 2023
PRIMARY
USAN
KL-177
Created by admin on Sat Dec 16 14:51:31 GMT 2023 , Edited by admin on Sat Dec 16 14:51:31 GMT 2023
PRIMARY
NCI_THESAURUS
C142077
Created by admin on Sat Dec 16 14:51:31 GMT 2023 , Edited by admin on Sat Dec 16 14:51:31 GMT 2023
PRIMARY
CAS
2231068-83-8
Created by admin on Sat Dec 16 14:51:31 GMT 2023 , Edited by admin on Sat Dec 16 14:51:31 GMT 2023
PRIMARY
From To
1_228 2_228
1_225 2_225
2_133 4_218
1_133 3_218
4_138 4_198
4_23 4_92
3_138 3_198
3_23 3_92
2_366 2_424
2_260 2_320
2_146 2_202
2_22 2_96
1_366 1_424
1_260 1_320
1_146 1_202
1_22 1_96
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL