Favezelimab

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:35:01 GMT 2025` Edited by `admin` on `Wed Apr 02 01:35:01 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	H1396W7D1H
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MK-4280

Preferred Name

English

Favezelimab

Official Name

English

MK4280

Code

English

Favezelimab [WHO-DD]

Common Name

English

MAVEZELIMAB

Common Name

English

favezelimab [INN]

Common Name

English

ANTI-LAG3 MONOCLONAL ANTIBODY MK-4280

Common Name

English

Immunoglobulin G4 [227-proline], anti-(human lymphocyte activation gene-3) (human-Mus musculus monoclonal C88 ?4-chain), disulfide with human-Mus musculus monoclonal C88 ?-chain, dimer

Common Name

English

Immunoglobulin G4-kappa, anti-[Homo sapiens LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223)], humanized monoclonal antibody; gamma4 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-58*01 (85.6%) -(IGHD) -IGHJ1*01 (91.7%)) [8.8.12] (1-

Common Name

English

FAVEZELIMAB [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C134305

Created by admin on Wed Apr 02 01:35:01 GMT 2025 , Edited by admin on Wed Apr 02 01:35:01 GMT 2025

Code System Code Type Description

INN

11179

Created by admin on Wed Apr 02 01:35:01 GMT 2025 , Edited by admin on Wed Apr 02 01:35:01 GMT 2025

PRIMARY

FDA UNII

H1396W7D1H

Created by admin on Wed Apr 02 01:35:01 GMT 2025 , Edited by admin on Wed Apr 02 01:35:01 GMT 2025

PRIMARY

USAN

KL-177

Created by admin on Wed Apr 02 01:35:01 GMT 2025 , Edited by admin on Wed Apr 02 01:35:01 GMT 2025

PRIMARY

SMS_ID

300000008665

Created by admin on Wed Apr 02 01:35:01 GMT 2025 , Edited by admin on Wed Apr 02 01:35:01 GMT 2025

PRIMARY

NCI_THESAURUS

C142077

Created by admin on Wed Apr 02 01:35:01 GMT 2025 , Edited by admin on Wed Apr 02 01:35:01 GMT 2025

PRIMARY

CAS

2231068-83-8

Created by admin on Wed Apr 02 01:35:01 GMT 2025 , Edited by admin on Wed Apr 02 01:35:01 GMT 2025

PRIMARY

From	To
1_228	2_228
1_225	2_225
2_133	4_218
1_133	3_218
4_138	4_198
4_23	4_92
3_138	3_198
3_23	3_92
2_366	2_424
2_260	2_320
2_146	2_202
2_22	2_96
1_366	1_424
1_260	1_320
1_146	1_202
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					AK0JDV1ZK5

LYMPHOCYTE ACTIVATION GENE 3 PROTEIN

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					H1396W7D1H

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_446] [2_446]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL