Neltependocel

Investigational

Approval Year

Substance Class	Structurally Diverse
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	eye
Fraction Material Type	cell
Fraction Name	corneal endothelial cells
Record UNII	GX6M5RT7MN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Allogeneic human corneal endothelial cells

Preferred Name

English

Neltependocel

Official Name

English

allogenic corneal endothelial cells derived from human corneal tissue (Descemet's membrane) and obtained by enzymatic digestion. The endothelial cells are seeded onto collagen type I-coated plates and expanded in media containing foetal bovine serum, cal

Common Name

English

neltependocel [INN]

Common Name

English

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Code System

Code

Type

Description

INN

12174

PRIMARY

FDA UNII

GX6M5RT7MN

PRIMARY

NCI_THESAURUS

C204146

PRIMARY

SMS_ID

300000054372

PRIMARY

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Related Record

Type

Details


					GX6M5RT7MN

Neltependocel

ACTIVE MOIETY

Comments:

cell therapy

Amount:

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Agent Modifications

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Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	Seeded onto collagen type I-coated plates and expanded in media MAP kinase inhibitor	Calcium Chloride	M4I0D6VV5M
CULTURE	EXPANSION	BIOLOGICAL	Seeded onto collagen type I-coated plates and expanded in media MAP kinase inhibitor	ASCORBIC ACID	PQ6CK8PD0R
CULTURE		BIOLOGICAL	Seeded onto collagen type I-coated plates and expanded in media MAP kinase inhibitor	CHONDROITIN SULFATE (BOVINE)	6IC1M3OG5Z
CULTURE	EXPANSION	BIOLOGICAL	Seeded onto collagen type I-coated plates and expanded in media MAP kinase inhibitor	Y-27632	0X370ROP6H
CULTURE	EXPANSION	BIOLOGICAL	Seeded onto collagen type I-coated plates and expanded in media MAP kinase inhibitor	FETAL SERUM, BOVINE	K5DD3J879P

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Name	Property Type	Referenced Substance
ANTIGEN NOT EXPRESSED	BIOLOGICAL	`UQ4V77A8VA` CD200

ANTIGEN NOT EXPRESSED	BIOLOGICAL	`49NQ5VN19N` DIPEPTIDYL PEPTIDASE 4 SOLUBLE FORM

ANTIGEN NOT EXPRESSED	BIOLOGICAL	`B20QL1Z44W` CD24

ANTIGEN EXPRESSED	BIOLOGICAL	`L4EL3BS2SO` CD166 ANTIGEN

ANTIGEN NOT EXPRESSED	BIOLOGICAL	`RIGEZF4K05` DIPEPTIDYL PEPTIDASE 4 MEMBRANE FORM

ANTIGEN NOT EXPRESSED	BIOLOGICAL	`7KI95LX9LZ` CD44 ANTIGEN

ANTIGEN NOT EXPRESSED	BIOLOGICAL	`1Y8Q34P575` ENDOGLIN