Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H13FN4O2 |
| Molecular Weight | 360.3412 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[O-][N+](=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(F)C=C4
InChI
InChIKey=BGIYKDUASORTBB-UHFFFAOYSA-N
InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
| Molecular Formula | C20H13FN4O2 |
| Molecular Weight | 360.3412 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/22913737
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/22913737
PD-169316 is a selective inhibitor of p38 MAPK. It inhibits p38 MAPK with an IC50 of 89 nM. PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. In an amyloid β (Aβ) rat model of Alzheimer's disease it was demonstrated that caspase-3 and Bax/Bcl-2 ratio, two marks of apoptosis, were significantly decreased in the rats pre-treated with PD169316 intracerebroventricularly.This study suggested the potential neuroprotective role of PD 169316 against the neuronal toxicity induced by Aβ.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells. | 2004 Mar |
|
| Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. | 2007 Jan |
|
| 15-Deoxy-Delta-Prostaglandin J(2) Upregulates the Expression of LPS-Induced IL-8/CXCL8 mRNA in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats. | 2009 Apr |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:09:02 GMT 2023
by
admin
on
Sat Dec 16 08:09:02 GMT 2023
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| Record UNII |
GX3Y2V80CV
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| Record Status |
Validated (UNII)
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| Record Version |
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GX3Y2V80CV
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4712
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DTXSID8042684
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152121-53-4
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admin on Sat Dec 16 08:09:02 GMT 2023 , Edited by admin on Sat Dec 16 08:09:02 GMT 2023
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| Related Record | Type | Details | ||
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TARGET -> INHIBITOR |
