ACAPATAMAB

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:53:21 GMT 2025` Edited by `admin` on `Tue Apr 01 22:53:21 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	GW5EID3IDO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACAPATAMAB

Official Name

English

acapatamab [INN]

Preferred Name

English

IMMUNOGLOBULIN, ANTI-(HUMAN PROSTATE-SPECIFIC MEMBRANE ANTIGEN) (HUMAN MONOCLONAL 76B10SCMABC SINGLE-CHAIN VARIABLE FRAGMENT VH1-(GGGGS)3-VL1) FUSION PROTEIN WITH PEPTIDE LINKER (GGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN ANTI-(HUMAN CD3 ANTIGEN .EPSILON.

Common Name

English

AMG-160

Code

English

MMUNOGLOBULIN SCFV-SCFV-SCFC, ANTI-(HOMO SAPIENS FOLH1 (FOLATE HYDROLASE, PROSTATE SPECIFIC MEMBRANE ANTIGEN, PSMA)) AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), MONOCLONAL ANTIBODY SINGLE CHAIN (SCFV)2-SCFC, BISPECIFIC

Common Name

English

Acapatamab [WHO-DD]

Common Name

English

ACAPATAMAB [USAN]

Common Name

English

Code System Code Type Description

FDA UNII

GW5EID3IDO

Created by admin on Tue Apr 01 22:53:21 GMT 2025 , Edited by admin on Tue Apr 01 22:53:21 GMT 2025

PRIMARY

USAN

JK-134

Created by admin on Tue Apr 01 22:53:21 GMT 2025 , Edited by admin on Tue Apr 01 22:53:21 GMT 2025

PRIMARY

CAS

2314491-93-3

Created by admin on Tue Apr 01 22:53:21 GMT 2025 , Edited by admin on Tue Apr 01 22:53:21 GMT 2025

PRIMARY

SMS_ID

300000033403

Created by admin on Tue Apr 01 22:53:21 GMT 2025 , Edited by admin on Tue Apr 01 22:53:21 GMT 2025

PRIMARY

NCI_THESAURUS

C175736

Created by admin on Tue Apr 01 22:53:21 GMT 2025 , Edited by admin on Tue Apr 01 22:53:21 GMT 2025

PRIMARY

INN

11421

Created by admin on Tue Apr 01 22:53:21 GMT 2025 , Edited by admin on Tue Apr 01 22:53:21 GMT 2025

PRIMARY

From	To
1_22	1_96
1_44	1_236
1_159	1_224
1_271	1_347
1_411	1_479
1_508	1_765
1_511	1_768
1_543	1_603
1_574	1_584
1_649	1_707
1_800	1_860
1_831	1_841
1_906	1_964

Related Record Type Details


					DRF6ZX9D07

PROSTATE SPECIFIC MEMBRANE ANTIGEN

TARGET->LIGAND

Amount:


					1U72JD9DDZ

T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN

TARGET->LIGAND

Amount:

Related Record Type Details


					GW5EID3IDO

ACTIVE MOIETY

Comments:

Redirects T effector cells to tumor cells via dual binding to CD3 and PSMA

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_986]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL