Trimethylhydroquinone (2,3,5-Trimethylhydroquinone, TMHQ) is a compound with a wide range of important practical applications. As shown by data from the patent literature, this compound can be used in the synthesis of dyes, pigments, antioxidants, polymerization inhibitors, and other important chemicals. However, the main use of this compound is as an intermediate in the industrial synthesis of vitamin E. Because of the importance of vitamin E in medicine, food manufacturing, and cattle breeding, there is continuing interest in the methods for the preparation of 2,3,5-trimethylhydroquinone. Trimethylhydroquinone presented obvious in vitro anti-MRSA activity.