RESOLVIN E1

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H30O5
Molecular Weight	350.4492
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	5
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@@H](O)\C=C\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O

InChI

InChIKey=AOPOCGPBAIARAV-OTBJXLELSA-N

InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)/b4-3+,9-5-,11-8+,12-6+,13-7-/t17-,18+,19-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H30O5
Molecular Weight	350.4492
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	5
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27543615 | https://www.ncbi.nlm.nih.gov/pubmed/29126887 | https://www.caymanchem.com/product/10007848 | https://clinicaltrials.gov/ct2/show/NCT00941018

Resolvin E1 (RvE1 or RX-10001) is a trihydroxy eicosapentaenoic acid metabolite that has a role as an anti-inflammatory agent and a human xenobiotic metabolite. This compound binds to leukotriene B4 (BLT-1) on neutrophils and to ERV-1/ChemR23 on monocyte/macrophages. Resolvin E1 has been shown to reverse experimental periodontitis and dysbiosis in rats. Furthermore, in a murine model of Alzheimer’s disease, Resolvin E1 (in combination with lipoxin A4) decreased neuroinflammation. Resolvin E1 was also suggested as a potential therapeutic target for psoriasis. A phase I clinical trial to test drug safety in healthy volunteers has been completed in 2009.

Approval Year

PubMed

Title	Date	PubMed
Resolvins: natural agonists for resolution of pulmonary inflammation.	2011-01	20887750
Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis.	2010-10	20709806
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.	2010-05	20383154
Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation.	2007-03-15	17339491
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.	2005-03-07	15753205

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:12:37 GMT 2025` Edited by `admin` on `Mon Mar 31 21:12:37 GMT 2025`
Record UNII	GND3JH08JA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RESOLVIN E1

Common Name

English

J2.218.407E

Preferred Name

English

5S,12R,18R-TRIHYDROXY-6Z,8E,10E,14Z,16E-EICOSAPENTAENOIC ACID

Systematic Name

English

(5S,6Z,8E,10E,12R,14Z,16E,18R)-5,12,18-TRIHYDROXY-6,8,10,14,16-EICOSAPENTAENOIC ACID

Systematic Name

English

RVE1

Common Name

English

6,8,10,14,16-EICOSAPENTAENOIC ACID, 5,12,18-TRIHYDROXY-, (5S,6Z,8E,10E,12R,14Z,16E,18R)-

Systematic Name

English

RX-10001

Code

English

Code System Code Type Description

CAS

552830-51-0