TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:34:28 GMT 2025` Edited by `admin` on `Wed Apr 02 06:34:28 GMT 2025`
Protein Type	ENZYME
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	GJD3Q7KT3S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROTEIN-TYROSINE PHOSPHATASE 1B

Preferred Name

English

TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1

Common Name

English

PTP-1B

Common Name

English

PTPN1 PROTEIN

Common Name

English

Code System Code Type Description

UNIPROT

P18031

Created by admin on Wed Apr 02 06:34:28 GMT 2025 , Edited by admin on Wed Apr 02 06:34:28 GMT 2025

PRIMARY

FDA UNII

GJD3Q7KT3S

Created by admin on Wed Apr 02 06:34:28 GMT 2025 , Edited by admin on Wed Apr 02 06:34:28 GMT 2025

PRIMARY

Linkage Type	Residue Index
Cys-Ser	1_215	1_216

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Amount:


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Comments:

With no pre-incubation the IC50 value for PTP1B(1– 405) was 600 nM, similar to that of MSI-1436; however, after a 30-min pre-incubation, the potency was improved to 100 nM. In contrast, there was no obvious time-dependent change in the IC50 value for PTP1B(1–321), suggesting that the C terminus of PTP1B was required for the difference in behavior of the two compounds. Activity is enhances in the presence of the cupric ion.

Qualification:

IC50

Amount:


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Amount:


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Amount:


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Interaction Type:

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Amount:

Structural Modifications

Modification Type	Location Site	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_50] [1_242] [1_243] [1_352] [1_363] [1_365] [1_378] [1_386]	DEXFOSFOSERINE	VI4F0K069V
AMINO_ACID_SUBSTITUTION	[1_20] [1_66]	TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO_ACID_SUBSTITUTION	[1_1]	N-ACETYLMETHIONINE	9J12WX5B6A

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL