Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 15:42:37 GMT 2023
by
admin
on
Sat Dec 16 15:42:37 GMT 2023
|
| Protein Type | ENZYME |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
GJD3Q7KT3S
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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P18031
Created by
admin on Sat Dec 16 15:42:37 GMT 2023 , Edited by admin on Sat Dec 16 15:42:37 GMT 2023
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PRIMARY | |||
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GJD3Q7KT3S
Created by
admin on Sat Dec 16 15:42:37 GMT 2023 , Edited by admin on Sat Dec 16 15:42:37 GMT 2023
|
PRIMARY |
| Linkage Type | Residue Index | |
|---|---|---|
| Cys-Ser | 1_215 | 1_216 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
With no pre-incubation the IC50 value for PTP1B(1– 405)
was 600 nM, similar to that of MSI-1436; however, after a
30-min pre-incubation, the potency was improved to 100 nM. In contrast, there was no obvious time-dependent change in the
IC50 value for PTP1B(1–321), suggesting that the C terminus of PTP1B was required for the difference in behavior of the two
compounds. Activity is enhances in the presence of the cupric ion.
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IN-VITRO
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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