SIBEPRENLIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:37:57 UTC 2023` Edited by `admin` on `Sat Dec 16 14:37:57 UTC 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2
Sequence Origin	HUMANIZED
Record UNII	GHX28QZ7DD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SIBEPRENLIMAB

Official Name

English

sibeprenlimab [INN]

Common Name

English

Immunogloabulin G2-kappa, anti-[Homo sapiens TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256)], humanized monoclonal antibody; gamma2 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-46*01 (85.7%) -(IGHD) -IGHJ4*01 (100%)) C

Common Name

English

Immunoglobulin G2, anti-(human proliferation-inducing ligand protein) (human monoclonal VIS649 γ2-chain), disulfide with human monoclonal VIS649 κ-chain, dimer

Common Name

English

VIS649

Code

English

SIBEPRENLIMAB [USAN]

Common Name

English

VIS-649

Code

English

Code System Code Type Description

INN

11575

Created by admin on Sat Dec 16 14:37:57 UTC 2023 , Edited by admin on Sat Dec 16 14:37:57 UTC 2023

PRIMARY

INN

CAS

2382896-07-1

Created by admin on Sat Dec 16 14:37:57 UTC 2023 , Edited by admin on Sat Dec 16 14:37:57 UTC 2023

PRIMARY

USAN

KL-40

Created by admin on Sat Dec 16 14:37:57 UTC 2023 , Edited by admin on Sat Dec 16 14:37:57 UTC 2023

PRIMARY

FDA UNII

GHX28QZ7DD

Created by admin on Sat Dec 16 14:37:57 UTC 2023 , Edited by admin on Sat Dec 16 14:37:57 UTC 2023

PRIMARY

NCI_THESAURUS

C179120

Created by admin on Sat Dec 16 14:37:57 UTC 2023 , Edited by admin on Sat Dec 16 14:37:57 UTC 2023

PRIMARY

From	To
1_22	1_96
1_147	1_203
1_222	2_222
1_223	2_223
1_229	2_229
1_226	2_226
1_260	1_320
1_366	1_424
2_22	2_96
2_147	2_203
2_260	2_320
2_366	2_424
3_23	3_92
3_138	3_198
1_134	3_218
4_23	4_92
2_134	4_218
4_138	4_198

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					75Y39ND994

TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					GHX28QZ7DD

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL