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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 00:29:01 GMT 2025
Edited
by admin
on Wed Apr 02 00:29:01 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG2
Sequence Origin HUMANIZED
Record UNII
GHX28QZ7DD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SIBEPRENLIMAB
USAN   INN  
Official Name English
VIS-649
Preferred Name English
sibeprenlimab [INN]
Common Name English
Immunogloabulin G2-kappa, anti-[Homo sapiens TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256)], humanized monoclonal antibody; gamma2 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-46*01 (85.7%) -(IGHD) -IGHJ4*01 (100%)) C
Common Name English
Sibeprenlimab [WHO-DD]
Common Name English
Immunoglobulin G2, anti-(human proliferation-inducing ligand protein) (human monoclonal VIS649 ?2-chain), disulfide with human monoclonal VIS649 ?-chain, dimer
Common Name English
VIS649
Code English
SIBEPRENLIMAB [USAN]
Common Name English
Code System Code Type Description
INN
11575
Created by admin on Wed Apr 02 00:29:02 GMT 2025 , Edited by admin on Wed Apr 02 00:29:02 GMT 2025
PRIMARY INN
CAS
2382896-07-1
Created by admin on Wed Apr 02 00:29:02 GMT 2025 , Edited by admin on Wed Apr 02 00:29:02 GMT 2025
PRIMARY
USAN
KL-40
Created by admin on Wed Apr 02 00:29:02 GMT 2025 , Edited by admin on Wed Apr 02 00:29:02 GMT 2025
PRIMARY
SMS_ID
300000005405
Created by admin on Wed Apr 02 00:29:02 GMT 2025 , Edited by admin on Wed Apr 02 00:29:02 GMT 2025
PRIMARY
FDA UNII
GHX28QZ7DD
Created by admin on Wed Apr 02 00:29:02 GMT 2025 , Edited by admin on Wed Apr 02 00:29:02 GMT 2025
PRIMARY
NCI_THESAURUS
C179120
Created by admin on Wed Apr 02 00:29:02 GMT 2025 , Edited by admin on Wed Apr 02 00:29:02 GMT 2025
PRIMARY
From To
1_22 1_96
1_147 1_203
1_222 2_222
1_223 2_223
1_229 2_229
1_226 2_226
1_260 1_320
1_366 1_424
2_22 2_96
2_147 2_203
2_260 2_320
2_366 2_424
3_23 3_92
3_138 3_198
1_134 3_218
4_23 4_92
2_134 4_218
4_138 4_198
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details
TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13
TARGET -> INHIBITOR
Related Record Type Details
SIBEPRENLIMAB
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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