FLUPREDNIDENE ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H29FO6
Molecular Weight	432.4819
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)OCC(=O)[C@@]1(O)C(=C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C

InChI

InChIKey=DEFOZIFYUBUHHU-IYQKUMFPSA-N

InChI=1S/C24H29FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,17-19,28,30H,1,5-6,9,11-12H2,2-4H3/t17-,18-,19-,21-,22-,23-,24-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H29FO6
Molecular Weight	432.4819
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.pharmazie.com/graphic/A/49/0-14349.pdf

Fluprednidene (used in a form of fluprednidene 21-acetate) is a glucocorticoid developed for the treatment of inflammatory skin diseases. The drug is marketed under the name Decoderm in Europe.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Inflammatory skin diseases 5 Sources: http://www.pharmazie.com/graphic/A/49/0-14349.pdf	Primary		Approved 8583	DECODERM Approved Use For the treatment of inflammatory skin diseases, for example, atopic eczema (atopic dermatitis, endogenous eczema), contact dermatitis.

Doses

Dose	Population	Adverse events
0.1 % single, topical Recommended Dose: 0.1 % Route: topical Route: single Dose: 0.1 % Sources: https://www.mims.com/singapore/drug/info/fluprednidene?mtype=generic	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://www.mims.com/singapore/drug/info/fluprednidene?mtype=generic	Disc. AE: Hypersensitivity... AEs leading to discontinuation/dose reduction: Hypersensitivity Sources: https://www.mims.com/singapore/drug/info/fluprednidene?mtype=generic

AEs

AE	Significance	Dose	Population
Hypersensitivity	Disc. AE	0.1 % single, topical Recommended Dose: 0.1 % Route: topical Route: single Dose: 0.1 % Sources: https://www.mims.com/singapore/drug/info/fluprednidene?mtype=generic	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://www.mims.com/singapore/drug/info/fluprednidene?mtype=generic

PubMed

Title	Date	PubMed
Double-blind comparison of miconazole/corticosteroid combination versus miconazole in inflammatory dermatomycoses.	1995-02	7737773
Dermal absorption of fluprednidene-21-acetate and miconazole from a new topical preparation in pigs.	1994-11	7848344
[Optimized interval treatment of eczema with fluprednidene. A multicenter double-blind study].	1989-09-15	2683439
Steroid-induced dermal atrophy. Investigations on discontinuous application.	1989	2529150

Patents

Sample Use Guides

In Vivo Use Guide

Apply the cream to the affected skin areas once a day.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:47:02 GMT 2025` Edited by `admin` on `Mon Mar 31 17:47:02 GMT 2025`
Record UNII	GE65DV564S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUPREDNIDENE ACETATE

Common Name

English

FLUPREDNIDENE ACETATE [MI]

Preferred Name

English

FLUPREDNIDENE ACETATE [MART.]

Common Name

English

Fluprednidene acetate [WHO-DD]

Common Name

English

Code System Code Type Description

MESH

C100064