TIRACIZINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H25N3O3.ClH
Molecular Weight	403.902
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCOC(=O)NC1=CC2=C(CCC3=C(C=CC=C3)N2C(=O)CN(C)C)C=C1

InChI

InChIKey=XJWABFCDXKZWPV-UHFFFAOYSA-N

InChI=1S/C21H25N3O3.ClH/c1-4-27-21(26)22-17-12-11-16-10-9-15-7-5-6-8-18(15)24(19(16)13-17)20(25)14-23(2)3;/h5-8,11-13H,4,9-10,14H2,1-3H3,(H,22,26);1H

HIDE SMILES / InChI

Molecular Formula	C21H25N3O3
Molecular Weight	367.4415
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9412062 | https://www.ncbi.nlm.nih.gov/pubmed/8527691

Tiracizine a drug belongs to the new class I antiarrhythmic agent was studied in patients with ischemic heart disease, where was shown, that the drug could decrease myocardial contractile function.

Approval Year

PubMed

Title	Date	PubMed
[Correction of the cardiotoxic effect of the anti-arrhythmia agents with befol, sufan, and their combination].	1998-06	9693756
[The anti-arrhythmia action of tiracizine in patients with ischemic heart disease and decreased myocardial contractile function].	1997-06	9412062
Day-night variations in the renal excretion of the antiarrhythmic agent tiracizine and its metabolites.	1995-04	8653799
Use dependent depression of fast sodium current in heart muscle by the new antiarrhythmic substance Bonnecor (AWD 19-166, GS 015).	1985-12	2419929

Patents

Sample Use Guides

In Vivo Use Guide

7-day multiple-dose study period (50 mg tiracizine twice daily)

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:51:35 GMT 2025` Edited by `admin` on `Mon Mar 31 19:51:35 GMT 2025`
Record UNII	GB5HGM31RA
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TIRACIZINE HYDROCHLORIDE

Common Name

English

BONNECOR

Preferred Name

English

CARBAMIC ACID, N-(5-(2-(DIMETHYLAMINO)ACETYL)-10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPIN-3-YL)-, ETHYL ESTER, HYDROCHLORIDE (1:1)

Common Name

English

AWD 19-166

Code

English

GS 015

Code

English

Tiracizine hydrochloride [WHO-DD]

Common Name

English

GS-015

Code

English

Code System Code Type Description

CAS

78816-67-8