BUROSUMAB

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	G9WJT6RD29
Record Status	`Validated (UNII)`
Record Version

Related Record	Type
No data available in table

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Name

Type

Language

BUROSUMAB

Official Name

English

KRN-23

Code

English

BUROSUMAB [JAN]

Common Name

English

burosumab [INN]

Common Name

English

BUROSUMAB [MI]

Common Name

English

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Classification Tree

Code System

Code

Designated/Approved

FDA ORPHAN DRUG

576217

Other drugs affecting bone structure and mineralization

WHO-ATC

M05BX05

Positive

EU-Orphan Drug

EU/3/18/2011

Designated/Approved

FDA ORPHAN DRUG

296109

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Code System

Code

Type

Description

DRUG CENTRAL

5282

PRIMARY

FDA UNII

G9WJT6RD29

PRIMARY

INN

10301

PRIMARY

MERCK INDEX

m12066

PRIMARY

CAS

1610833-03-8

PRIMARY

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From	To
1_22	1_96
1_144	1_200
1_220	3_213
1_226	2_226
1_229	2_229

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Glycosylation Type

MAMMALIAN

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Glycosylation Link Type	Site
N	1_297
N	2_297

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Related Record

Type

Details

BUROSUMAB-TWZA

INNOVATOR->PARENT

Amount:


					7Q7P4S7RRE

FIBROBLAST GROWTH FACTOR 23

TARGET -> INHIBITOR

BUROSUMAB-TWZA

SUB_CONCEPT->SUBSTANCE

Amount:

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Related Record

Type

Details


					G9WJT6RD29

BUROSUMAB

ACTIVE MOIETY

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Name	Property Type	Amount
Molecular Formula	CHEMICAL	ESTIMATED C6388H9888N1700O2006S46
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 144000 Da (average)
Volume of Distribution	PHARMACOKINETIC	0.11 Liters/Kilogram (average)

Biological Half-life	PHARMACOKINETIC	19 days (average)