FALLYPRIDE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H29FN2O3
Molecular Weight	364.4543
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(CCCF)=CC(C(=O)NC[C@@H]2CCCN2CC=C)=C1OC

InChI

InChIKey=OABRYNHZQBZDMG-INIZCTEOSA-N

InChI=1S/C20H29FN2O3/c1-4-10-23-11-6-8-16(23)14-22-20(24)17-12-15(7-5-9-21)13-18(25-2)19(17)26-3/h4,12-13,16H,1,5-11,14H2,2-3H3,(H,22,24)/t16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H29FN2O3
Molecular Weight	364.4543
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17765546/ | https://www.ncbi.nlm.nih.gov/pubmed/7627142 | https://www.ncbi.nlm.nih.gov/pubmed/10473190 | https://www.ncbi.nlm.nih.gov/pubmed/26422464

Fallypride is a high-affinity antagonist of dopamine D2 and D3 receptors. 18F-radiolabeled fallypride is used as a PET tracer to characterize D2/D3 receptors in the brain.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
D(2) dopamine receptor 58 Target ID: P14416 Gene ID: 1813.0 Gene Symbol: DRD2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17765546/ \| https://www.ncbi.nlm.nih.gov/pubmed/10473190	Antagonist 2778		2.1 nM [Ki]
D(3) dopamine receptor 16 Target ID: P35462 Gene ID: 1814.0 Gene Symbol: DRD3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17765546/ \| https://www.ncbi.nlm.nih.gov/pubmed/10473190	Antagonist 2778		1.6 nM [Ki]

PubMed

Title	Date	PubMed
Fluorinated benzamide neuroleptics--III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer.	1995 Apr	7627142
PET tracers for imaging of the dopaminergic system.	2006	16918344
In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors.	2007 Nov 1	17765546
Dopamine D3 receptor binding of (18)F-fallypride: Evaluation using in vitro and in vivo PET imaging studies.	2015 Dec	26422464

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:28:38 UTC 2023` Edited by `admin` on `Sat Dec 16 08:28:38 UTC 2023`
Record UNII	G9FWZ369GX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FALLYPRIDE

Common Name

English

BENZAMIDE, 5-(3-FLUOROPROPYL)-2,3-DIMETHOXY-N-(((2S)-1-(2-PROPEN-1-YL)-2-PYRROLIDINYL)METHYL)-

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

Fallypride