Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H28O7P2 |
| Molecular Weight | 382.3261 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)=CCC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
InChI
InChIKey=VWFJDQUYCIWHTN-YFVJMOTDSA-N
InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
| Molecular Formula | C15H28O7P2 |
| Molecular Weight | 382.3261 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Purification and regulation of mevalonate kinase from rat liver. | 1990 Feb 5 |
|
| Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase. | 1992 Apr 25 |
|
| Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. | 1997 Nov |
|
| Determination of farnesyl pyrophosphate in dog and human plasma by high-performance liquid chromatography with fluorescence detection. | 1997 Oct 1 |
|
| Truncation of human squalene synthase yields active, crystallizable protein. | 1998 Feb 15 |
|
| The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. | 2000 Feb 15 |
|
| Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. | 2000 Sep 1 |
|
| Tissue-specific transcriptional regulation of the cholesterol biosynthetic pathway leads to accumulation of testis meiosis-activating sterol (T-MAS). | 2002 Jan |
|
| A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents. | 2003 Jul 3 |
|
| Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2. | 2003 Nov 1 |
|
| Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. | 2004 |
|
| Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. | 2004 Jul 16 |
|
| Lovastatin-induced apoptosis in human melanoma cell lines. | 2005 Apr |
|
| Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. | 2005 Aug 1 |
|
| Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. | 2005 Jun 10 |
|
| Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. | 2007 Feb 23 |
|
| Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer. | 2007 Jul 6 |
|
| The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis. | 2007 Oct |
|
| Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism. | 2008 Jul |
|
| Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. | 2008 Mar |
|
| Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. | 2008 Mar 25 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 20:20:22 UTC 2023
by
admin
on
Sat Dec 16 20:20:22 UTC 2023
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| Record UNII |
G8X8WT527W
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| Record Status |
Validated (UNII)
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| Record Version |
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Created by
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