TAMPRAMINE FUMARATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H24N4.C4H4O4
Molecular Weight	472.5356
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C\C(O)=O.CN(C)CCCN1C2=C(C=CC=C2)C(=NC3=C1N=CC=C3)C4=CC=CC=C4

InChI

InChIKey=USQAILMOWHOBTK-WLHGVMLRSA-N

InChI=1S/C23H24N4.C4H4O4/c1-26(2)16-9-17-27-21-14-7-6-12-19(21)22(18-10-4-3-5-11-18)25-20-13-8-15-24-23(20)27;5-3(6)1-2-4(7)8/h3-8,10-15H,9,16-17H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

HIDE SMILES / InChI

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	C23H24N4
Molecular Weight	356.4635
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6548381 | https://www.ncbi.nlm.nih.gov/pubmed/3936083 | https://adisinsight.springer.com/drugs/800000569

Tampramine (also known as AHR-9377) is a potent and selective, noncompetitive inhibitor of norepinephrine reuptake possesses antidepressant activity. This drug was studied for the treatment of the major depressive disorder; however, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake.	1984 Oct 1	6548381
Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate.	1985	3936083

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:13:28 GMT 2023` Edited by `admin` on `Fri Dec 15 15:13:28 GMT 2023`
Record UNII	G81BBX0DG1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TAMPRAMINE FUMARATE

Official Name

English

AHR-9377

Code

English

TAMPRAMINE FUMARATE [USAN]

Common Name

English

11H-PYRIDO(2,3-B)(1,4)BENZODIAZEPINE-11-PROPANAMINE, N,N-DIMETHYL-6-PHENYL-, (E)-2-BUTENEDIOATE (1:1)

Systematic Name

English

11-[3-(Dimethylamino)propyl]-6-phenyl-11H-pyrido[2,3-b][1,4]benzodiazepine fumarate (1:1)

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C94727