Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H12N2O.C4H7N3O.H2O4S |
| Molecular Weight | 387.411 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(O)(=O)=O.CN1CC(=O)N=C1N.NCCC2=CNC3=C2C=C(O)C=C3
InChI
InChIKey=WFZKRNIMSVDNBU-UHFFFAOYSA-N
InChI=1S/C10H12N2O.C4H7N3O.H2O4S/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;1-7-2-3(8)6-4(7)5;1-5(2,3)4/h1-2,5-6,12-13H,3-4,11H2;2H2,1H3,(H2,5,6,8);(H2,1,2,3,4)
| Molecular Formula | C10H12N2O |
| Molecular Weight | 176.2151 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C4H7N3O |
| Molecular Weight | 113.1179 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | H2O4S |
| Molecular Weight | 98.078 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter produced by serotonergic neurons in the CNS and enterochromaffin cells in the gastrointestinal tract. Pharmacologic action of serotonin is mediated by a large and diverse range of 5-HT receptors. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder, and anxiety. It is also believed to be influential on sexuality and appetite. Creatinine is a product of the metabolic breakdown of creatine phosphate in muscle. Creatinine is filtered by healthy kidneys. Serotonin creatinine sulfate complex was the first isolated salt form of serotonin.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Lethal effect of the serotonin-xylocaineR association in ganglion-blocked rats. | 1976 Dec |
|
| Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines. | 2000 Feb |
|
| [Anorectics and pulmonary hypertension]. | 2000 Feb 16 |
|
| The effect of fenfluramine on the pulmonary disposition of 5-hydroxytryptamine in the isolated perfused rat lung: a comparison with chlorphentermine. | 2000 Jan |
|
| Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit. | 2000 Jul 7 |
|
| Probing the role of a conserved M1 proline residue in 5-hydroxytryptamine(3) receptor gating. | 2000 Jun |
|
| Inverse agonism and constitutive activity as functional correlates of serotonin h5-HT(1B) receptor/G-protein stoichiometry. | 2000 Nov |
|
| Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5. | 2000 Nov |
|
| A clinical trial on a plate? The potential of 384-well format solid phase extraction for high-throughput bioanalysis using liquid chromatography/tandem mass spectrometry. | 2001 |
|
| Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain. | 2001 |
|
| Constitutive activity at serotonin 5-HT(1D) receptors: detection by homologous GTPgammaS versus [(35)S]-GTPgammaS binding isotherms. | 2001 |
|
| Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. | 2001 Apr 6 |
|
| Evidence for a serotonin transporter deficit in experimental acute liver failure. | 2001 Feb |
|
| Endogenous 5-HT tonically inhibits spontaneous firing activity of dorsal hippocampus CA1 pyramidal neurons through stimulation of 5-HT(1A) receptors in quiet awake rats: in vivo electrophysiological evidence. | 2001 Feb |
|
| Neuroendocrine and behavioral responses to mCPP in Obsessive-Compulsive Disorder. | 2001 Feb |
|
| Functional role of critical stripe residues in transmembrane span 7 of the serotonin transporter. Effects of Na+, Li+, and methanethiosulfonate reagents. | 2001 Feb 9 |
|
| Radiosynthesis of [123I]betaCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain. | 2001 Jan |
|
| Changes of biogenic amine levels in haemolymph during diapausing and non-diapausing status in Pieris brassicae L. | 2001 Jan |
|
| A novel augmentation strategy for treating resistant major depression. | 2001 Jan |
|
| Depression among pregnant adolescents: an integrated treatment approach. | 2001 Jan |
|
| Ondansetron hydrochloride for the treatment of delirium after coronary artery surgery. | 2001 Jan |
|
| Prevention of galanin upregulation following neonatal infraorbital nerve transection or attenuation of axoplasmic transport does not rescue central vibrissae-related patterns in the rat. | 2001 Jan |
|
| Necessity of thromboxane A2 for initiation of platelet-mediated contact sensitivity: dual activation of platelets and vascular endothelial cells. | 2001 Jan 1 |
|
| Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomography provocation study. | 2001 Jan 12 |
|
| Serum pancreastatin levels predict response to hepatic artery chemoembolization and somatostatin analogue therapy in metastatic neuroendocrine tumors. | 2001 Jan 12 |
|
| Mapping of 5-HT2A receptors and their mRNA in monkey brain: [3H]MDL100,907 autoradiography and in situ hybridization studies. | 2001 Jan 22 |
|
| Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo. | 2001 Jan 5 |
|
| M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex. | 2001 Jan 5 |
|
| Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom. | 2001 Jun |
|
| Functional reconstitution and characterization of recombinant human alpha 1-glycine receptors. | 2001 Jun 15 |
|
| The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. | 2001 Mar 16 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:24:36 GMT 2023
by
admin
on
Sat Dec 16 09:24:36 GMT 2023
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| Record UNII |
G63220IH3V
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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1013025-55-2
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971-74-4
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213-539-3
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G63220IH3V
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25713-03-5
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379432
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13781
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