LENIQUINSIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H20N2O4
Molecular Weight	352.3838
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=NC2=CC=NC3=C2C=C(OC)C(OC)=C3)C=C1OC

InChI

InChIKey=JIGAQXOHSFIRIS-UUYOSTAYSA-N

InChI=1S/C20H20N2O4/c1-23-17-6-5-13(9-18(17)24-2)12-22-15-7-8-21-16-11-20(26-4)19(25-3)10-14(15)16/h5-12H,1-4H3/b22-12-

HIDE SMILES / InChI

Molecular Formula	C20H20N2O4
Molecular Weight	352.3838
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6276530 | http://glixxlabs.com/chemical-products/bioactive-screen-leads-p6/GLXC-12635 | Martin-Smith, M. et al. (2013) Progress in Drug Research, page 124, retrieved from: https://books.google.ru/books?id=B4P1BwAAQBAJ

Leniquinsin acts as a vasodilator and shows antihypertensive effects. It is a potent rat brain phosphodiesterase inhibitor. Its hypotensive effect would seem to be due to alpha-adrenergic blockade and to a direct action on smooth muscle.

Approval Year

PubMed

Title	Date	PubMed
Synthesis and hypotensive properties of new 4-aminoquinolines.	1971 Nov	5115204
Heterogeneity of biochemical actions among vasodilators.	1982 Jan	6276530

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:05:55 UTC 2023` Edited by `admin` on `Fri Dec 15 15:05:55 UTC 2023`
Record UNII	G53DC63OCM
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LENIQUINSIN

Official Name

English

EU-1085

Code

English

leniquinsin [INN]

Common Name

English

6,7-Dimethoxy-4-(veratrylideneamino)quinoline

Systematic Name

English

LENIQUINSIN [USAN]

Common Name

English

4-QUINOLINAMINE, N-((3,4-DIMETHOXYPHENYL)METHYLENE)-6,7-DIMETHOXY-

Systematic Name

English

NSC-201115

Code

English

Code System Code Type Description

FDA UNII

G53DC63OCM