8-Aminoadenine

NC1=NC2=NC=NC(N)=C2N1

InChIKey=PFUVOLUPRFCPMN-UHFFFAOYSA-N

InChI=1S/C5H6N6/c6-3-2-4(9-1-8-3)11-5(7)10-2/h1H,(H5,6,7,8,9,10,11)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Phosphatidylinositol 4-kinase, PI4K 8 Target ID: CHEMBL2096619 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2165159	Inhibitor 8504
Mas-related G-protein coupled receptor member X3 2 Target ID: Q96LB0 Gene ID: 117195.0 Gene Symbol: MRGPRX3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/19731917	Agonist 2752	34.1 nM [Ki]
UniProtKB - Q96LB0 (MRGX3_HUMAN) 2 Target ID: UniProtKB - Q96LB0 (MRGX3_HUMAN) Sources: https://www.ncbi.nlm.nih.gov/pubmed/19731917	Agonist 2752	6.51 µM [Ki]

PubMed

Title	Date	PubMed
Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.	2009-10-08	19731917

Substance Class	Chemical Created by `admin` on `Wed Apr 02 12:02:07 GMT 2025` Edited by `admin` on `Wed Apr 02 12:02:07 GMT 2025`
Record UNII	G45ND69PRK
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

8-Aminoadenine

Systematic Name

English

NSC-21698

Preferred Name

English

Purine, 6,8-diamino-

Systematic Name

English

9H-Purine-6,8-diamine

Systematic Name

English

1H-Purine-6,8-diamine

Systematic Name

English

Code System Code Type Description

NSC

21698