Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H12N4 |
| Molecular Weight | 212.2505 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C(N)=NC2=C1C(C)=CC3=C2C=CC=N3
InChI
InChIKey=GMGWMIJIGUYNAY-UHFFFAOYSA-N
InChI=1S/C12H12N4/c1-7-6-9-8(4-3-5-14-9)10-11(7)16(2)12(13)15-10/h3-6H,1-2H3,(H2,13,15)
| Molecular Formula | C12H12N4 |
| Molecular Weight | 212.2505 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx. | 1985 |
|
| Carcinogenicity in mice and rats of heterocyclic amines in cooked foods. | 1986 Aug |
|
| Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. | 1989 Jun 15 |
|
| Mutation, loss of heterozygosity, and recombination of the p53 gene in mouse forestomach tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline. | 1995 Jan |
|
| Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains. | 2001 |
|
| Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon. | 2001 Feb |
|
| LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences. | 2001 Jun 2 |
|
| Mutagenicity of food-derived carcinogens and the effect of antioxidant vitamins. | 2002 |
|
| Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats. | 2002 |
|
| Inhibitory effect of curcumin and its natural analogues on genotoxicity of heterocyclic amines from cooked food. | 2002 Dec |
|
| Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats. | 2002 Feb |
|
| Effects of soy sauce and sugar on the formation of heterocyclic amines in marinated foods. | 2002 Jul |
|
| Antimutagenic activities of various lactic acid bacteria against food mutagens: heterocyclic amines. | 2002 May |
|
| Inhibitory effect of dibenzoylmethane on mutagenicity of food-derived heterocyclic amine mutagens. | 2003 |
|
| Regional mutagenicity of heterocyclic amines in the intestine: mutation analysis of the cII gene in lambda/lacZ transgenic mice. | 2003 Aug 5 |
|
| Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice. | 2003 Jul 30 |
|
| Uptake of heterocyclic aromatic amine by insoluble dietary fiber in artificial gastric and intestinal juice. | 2004 Mar |
|
| Determination of heterocyclic aromatic amines (HAs) content in samples of household-prepared meat dishes. | 2004 Mar 25 |
|
| Lack of formation of heterocyclic amines in fumes from frying French fries. | 2006 Sep |
|
| Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. | 2006 Sep 1 |
|
| Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia. | 2009 Jul 21 |
|
| Naturally occurring food toxins. | 2010 Sep |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:25:46 UTC 2023
by
admin
on
Fri Dec 15 18:25:46 UTC 2023
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| Record UNII |
G2Q7M1P33X
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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DTXSID6020800
Created by
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77094-11-2
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7766
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62274
Created by
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G2Q7M1P33X
Created by
admin on Fri Dec 15 18:25:46 UTC 2023 , Edited by admin on Fri Dec 15 18:25:46 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine skin content in cooked food sample. 375?52 pg/g sample.
Heterocyclic amine flesh content in cooked food sample. 67 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine content in cooked food sample. 424?87 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine flesh content in cooked food sample. 180 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine skin content in cooked food sample. 317?14 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine in cooked meat sample. 86?12 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine in cooked meat sample. 142?22 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Semi-Dried(Aji-Hiraki) JAPANESE HORSE MACKEREL SKIN, COOKED
Heterocyclic amine skin content in cooked food sample. 262?41 pg/g sample.
Heterocyclic amine flesh content in cooked food sample. 70 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine skin content in cooked food sample. 435?57 pg/g sample.
Heterocyclic amine flesh content in cooked food sample. 98 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine flesh content in cooked food sample. 319 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine in well cooked meat sample. 94?12 pg/g sample.
Heterocyclic amine in medium cooked meat sample. 125?31 pg/g sample.
|
