Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H12N4 |
| Molecular Weight | 212.2505 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C(N)=NC2=C1C(C)=CC3=C2C=CC=N3
InChI
InChIKey=GMGWMIJIGUYNAY-UHFFFAOYSA-N
InChI=1S/C12H12N4/c1-7-6-9-8(4-3-5-14-9)10-11(7)16(2)12(13)15-10/h3-6H,1-2H3,(H2,13,15)
| Molecular Formula | C12H12N4 |
| Molecular Weight | 212.2505 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Induction of tumors in the Zymbal gland, oral cavity, colon, skin and mammary gland of F344 rats by a mutagenic compound, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline. | 1989 Mar |
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| Detection of a Ha-ras point mutation by polymerase chain reaction-single strand conformation polymorphism analysis in 2-amino-3,4-dimethylimidazo[4,5-f]quinoline-induced mouse forestomach tumors. | 1992 Feb 29 |
|
| Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2. | 1992 May 1 |
|
| Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods. | 1994 Aug 1 |
|
| Mutation, loss of heterozygosity, and recombination of the p53 gene in mouse forestomach tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline. | 1995 Jan |
|
| Chromosome aberrations induced in mice by chronic feeding of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ). | 1998 Jun |
|
| No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice. | 1998 May 25 |
|
| Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocylic amines. | 1999 Sep 1 |
|
| Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. | 2002 Jan |
|
| Human prostate epithelial cells metabolize chemicals of dietary origin to mutagens. | 2002 Jan 25 |
|
| Effects of soy sauce and sugar on the formation of heterocyclic amines in marinated foods. | 2002 Jul |
|
| Effects of dairy products on heterocyclic aromatic amine-induced rat colon carcinogenesis. | 2002 Mar |
|
| Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas. | 2002 Mar |
|
| Antimutagenic activities of various lactic acid bacteria against food mutagens: heterocyclic amines. | 2002 May |
|
| Mammary gland carcinogenesis by food-derived heterocyclic amines and studies on the mechanisms of carcinogenesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). | 2002 Sep 30 |
|
| Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment. | 2005 Apr |
|
| Suppression of chemical mutagen-induced SOS response by allylbenzen from Asiasarum heterotropoides in the Salmonella typhimurium TA1535/PSK1002 umu test. | 2005 Jan |
|
| Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity. | 2005 Oct 25 |
|
| Suppression of MeIQ-induced SOS response by allylbenzenes from Asiasarum heterotropoides in the Salmonella typhimurium OY1001/1A2 umu test. | 2006 Jun |
|
| Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. | 2006 Sep 1 |
|
| Validation of an in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expression. | 2010 Apr |
|
| Determination of heterocyclic amines in urine samples by capillary liquid chromatography with evaporated light-scattering detection. | 2010 May |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:25:46 GMT 2023
by
admin
on
Fri Dec 15 18:25:46 GMT 2023
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| Record UNII |
G2Q7M1P33X
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| Record Status |
Validated (UNII)
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| Record Version |
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| Code System | Code | Type | Description | ||
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DTXSID6020800
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77094-11-2
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7766
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62274
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G2Q7M1P33X
Created by
admin on Fri Dec 15 18:25:46 GMT 2023 , Edited by admin on Fri Dec 15 18:25:46 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine skin content in cooked food sample. 375?52 pg/g sample.
Heterocyclic amine flesh content in cooked food sample. 67 pg/g sample.
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|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine content in cooked food sample. 424?87 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine flesh content in cooked food sample. 180 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine skin content in cooked food sample. 317?14 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine in cooked meat sample. 86?12 pg/g sample.
|
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine in cooked meat sample. 142?22 pg/g sample.
|
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|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Semi-Dried(Aji-Hiraki) JAPANESE HORSE MACKEREL SKIN, COOKED
Heterocyclic amine skin content in cooked food sample. 262?41 pg/g sample.
Heterocyclic amine flesh content in cooked food sample. 70 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine skin content in cooked food sample. 435?57 pg/g sample.
Heterocyclic amine flesh content in cooked food sample. 98 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine flesh content in cooked food sample. 319 pg/g sample.
|
||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Heterocyclic amine in well cooked meat sample. 94?12 pg/g sample.
Heterocyclic amine in medium cooked meat sample. 125?31 pg/g sample.
|
