SCH-900271

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H16N2O4
Molecular Weight	276.2878
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC3(CCCC1=CC(=O)OC2=C1C(=O)NC(=O)N2)CC3

InChI

InChIKey=ARJKMWXLIHZLQZ-UHFFFAOYSA-N

InChI=1S/C14H16N2O4/c1-14(5-6-14)4-2-3-8-7-9(17)20-12-10(8)11(18)15-13(19)16-12/h7H,2-6H2,1H3,(H2,15,16,18,19)

HIDE SMILES / InChI

Molecular Formula	C14H16N2O4
Molecular Weight	276.2878
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT00941603 | https://www.ncbi.nlm.nih.gov/pubmed/24900372 | https://adisinsight.springer.com/drugs/800030664

SCH 900271 was studied as a potent nicotinic acid receptor agonist for the Treatment of Dyslipidemia. This compound participated in a phase II clinical trial to evaluate its efficacy and safety in participants with primary hypercholesterolemia or mixed hyperlipidemia. However, apparently, the further development of SCH 900271 had been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.	2012 Jan 12	24900372

Sample Use Guides

In Vivo Use Guide

Participants receive SCH 900271 1-15 mg tablet and placebo tablet once daily in the morning with water in a fasted state for 8 weeks

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:01:40 GMT 2023` Edited by `admin` on `Sat Dec 16 04:01:40 GMT 2023`
Record UNII	G2283XQ6VJ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SCH-900271

Common Name

English

2H-PYRANO(2,3-D)PYRIMIDINE-2,4,7(1H,3H)-TRIONE, 5-(3-(1-METHYLCYCLOPROPYL)PROPYL)-

Systematic Name

English

SCH 900271

Code

English

5-(3-(1-METHYLCYCLOPROPYL)PROPYL)-1H-PYRANO(2,3-D)PYRIMIDINE-2,4,7(3H)-TRIONE

Systematic Name

English

Code System Code Type Description

PUBCHEM

56950369