HYDROCORTISONE TEBUTATE

US Previously Marketed

First approved in 1955

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H40O6
Molecular Weight	460.6029
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C

InChI

InChIKey=FNFPHNZQOKBKHN-KAJVQRHHSA-N

InChI=1S/C27H40O6/c1-24(2,3)14-22(31)33-15-21(30)27(32)11-9-19-18-7-6-16-12-17(28)8-10-25(16,4)23(18)20(29)13-26(19,27)5/h12,18-20,23,29,32H,6-11,13-15H2,1-5H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H40O6
Molecular Weight	460.6029
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
258 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2050835	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:		HYDROCORTISONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
1175 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2050835	20 mg single, intravenous dose: 20 mg route of administration: Intravenous experiment type: SINGLE co-administered:		HYDROCORTISONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
1162 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2050835	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:		HYDROCORTISONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
1.66 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2050835	20 mg single, intravenous dose: 20 mg route of administration: Intravenous experiment type: SINGLE co-administered:	HYDROCORTISONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
1.82 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2050835	20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered:	HYDROCORTISONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
1.5 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213876s000lbl.pdf	unknown, oral	HYDROCORTISONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
10% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213876s000lbl.pdf	unknown, oral		HYDROCORTISONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
Alfa Chemistry	508-96-3	https://www.alfa-chemistry.com/cas_508-96-3.htm
ChemTik	CTK4J3315
ZINC	ZINC000038605928	http://zinc15.docking.org/substances/ZINC000038605928

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:56:06 GMT 2025` Edited by `admin` on `Mon Mar 31 17:56:06 GMT 2025`
Record UNII	FXJ67LWZ4S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HYDROCORTISONE TEBUTATE

Common Name

English

CORTISOL, 21-(3,3-DIMETHYLBUTYRATE)

Preferred Name

English

HYDROCORTISONE TERT-BUTYLACETATE

Common Name

English

Code System Code Type Description

FDA UNII

FXJ67LWZ4S