TIMELOTEM, (-)-

Details

Stereochemistry	UNKNOWN
Molecular Formula	C17H18FN3S
Molecular Weight	315.408
Optical Activity	( - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN2C(C1)CN=C(C3=CC=CS3)C4=C2C=C(F)C=C4

InChI

InChIKey=ICHHTOMWWAMJQP-UHFFFAOYSA-N

InChI=1S/C17H18FN3S/c1-20-6-7-21-13(11-20)10-19-17(16-3-2-8-22-16)14-5-4-12(18)9-15(14)21/h2-5,8-9,13H,6-7,10-11H2,1H3

HIDE SMILES / InChI

Molecular Formula	C17H18FN3S
Molecular Weight	315.408
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2889124 | https://www.ncbi.nlm.nih.gov/pubmed/2889744

Timelotem is a benzodiazepine derivative patented by Kali-Chemie Pharma G.m.b.H. as an anesthetic agent. In preclinical models, Timelotem shows atypical antipsychotic activity. Timelotem antagonizes DL-2-amino-5-phosphonovaleric acid (AP-5)-induced sniffing and the body turns in rats. Further, Timelotem antagonized amphetamine-induced stereotyped behavior in rats but was found less active than haloperidol in this test.

Originator

Approval Year

PubMed

Title	Date	PubMed
Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol.	1987 Oct 19	2889124

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:15:04 GMT 2023` Edited by `admin` on `Sat Dec 16 10:15:04 GMT 2023`
Record UNII	FW973BEK25
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TIMELOTEM, (-)-

Common Name

English

PYRAZINO(1,2-A)(1,4)BENZODIAZEPINE, 10-FLUORO-1,2,3,4,4A,5-HEXAHYDRO-3-METHYL-7-(2-THIENYL)-, (-)-

Systematic Name

English

Code System Code Type Description

FDA UNII

FW973BEK25

Created by admin on Sat Dec 16 10:15:04 GMT 2023 , Edited by admin on Sat Dec 16 10:15:04 GMT 2023

PRIMARY

CAS

120106-98-1