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Details

Stereochemistry ACHIRAL
Molecular Formula H3P
Molecular Weight 33.99758
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHOSPHINE

SMILES

P

InChI

InChIKey=XYFCBTPGUUZFHI-UHFFFAOYSA-N
InChI=1S/H3P/h1H3

HIDE SMILES / InChI

Molecular Formula H3P
Molecular Weight 33.99758
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Phosphine carries the chemical formula of PH3. The concentration of this compound constantly alters in our environment. Phosphine is an important agricultural fumigant with pulmonary and systemic toxicity that is generated on site as a gas given off by moisture coming in contact with solid form aluminum or zinc phosphide (e.g., in grain storage facilities or railway grain transport cars, where bystanders can be exposed). Phosphine also has industrial applications, particularly in the production of microelectronics. Symptoms such as diarrhea, nausea and vomiting, tightness of the chest, cough, headache, and dizziness have been reported in workers exposed intermittently to concentrations up to 35 ppm.

Approval Year

PubMed

PubMed

TitleDatePubMed
Cholestatic presentation of yellow phosphorus poisoning.
2014-01
Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.
2012-01
X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury.
2011-02
Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human vascular smooth muscle cells.
2007-11
Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro.
2007-11
Effects of the administration of corticosterone, parathyroid hormone, or both, and of their withdrawal, on rat bone and cartilage histomorphometric parameters, and on osteoprotegerin and RANKL mRNA expression and proteins.
2007-06
Disruption of iron homeostasis increases phosphine toxicity in Caenorhabditis elegans.
2007-03
Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1.
2006-01
Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice.
2005-12
[Effects of intermittent treatment with sevelamer hydrochloride on parathyroid hyperplasia and vascular calcification in rats with chronic kidney disease].
2005-09
Functional characteristics of NaS2, a placenta-specific Na+-coupled transporter for sulfate and oxyanions of the micronutrients selenium and chromium.
2005-01-25
Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda.
2005
FGF-23 is elevated by chronic hyperphosphatemia.
2004-09
A comparison of clinically useful phosphorus binders for patients with chronic kidney failure.
2004-09
Electrolyte concentrations in saliva of children aged 6-10 years with Down syndrome.
2004-07
Expression of collagen XVIII and MMP-20 in developing teeth and odontogenic tumors.
2004-06
Beneficial effect of liver transplantation on bone mineral density in small infants with cholestasis.
2004-06
Neural damage due to temporal lobe epilepsy: dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study.
2004-02
Relation of salivary inorganic phosphorus and alkaline phosphatase to the dental caries status in children.
2003-12
Calcification mimicking manganese-induced increased signal intensities in T1-weighted MR images in a patient taking herbal medicine: case report.
2003-12
Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials.
2003-12
A case of oncogenic osteomalacia detected by 111In-pentetreotide total body scan.
2003-08-29
Calcimimetic agents: review and perspectives.
2003-06
Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production.
2003-01-24
Pathogenesis and treatment of renal osteodystrophy.
2003
Effects of PHEX antisense in human osteoblast cells.
2002-02
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
2002-02
Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism.
2001-09
31Phosphorus magnetic resonance spectroscopy in late-onset Tay-Sachs disease.
2001-05
Chromosome rearrangements in fumigant appliers: possible relationship to non-Hodgkin's lymphoma risk.
1992-05-11
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:35:03 GMT 2025
Edited
by admin
on Mon Mar 31 21:35:03 GMT 2025
Record UNII
FW6947296I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TK-GAS
Preferred Name English
PHOSPHINE
HSDB   MI  
Systematic Name English
PHOSPHORUS HYDRIDE
Systematic Name English
HYDROGEN PHOSPHIDE
Common Name English
PHOSPHINE [HSDB]
Common Name English
PHOSPHINE [MI]
Common Name English
PHOSPHORUS TRIHYDRIDE
Systematic Name English
PHOSPHINE (PH3)
Common Name English
VAPORPHOS
Brand Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 66500
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
Code System Code Type Description
MESH
C044646
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
ECHA (EC/EINECS)
232-260-8
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
ALANWOOD
phosphine
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
PUBCHEM
24404
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
FDA UNII
FW6947296I
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
MERCK INDEX
m8720
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY Merck Index
SMS_ID
300000049794
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
CHEBI
30278
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
CAS
7803-51-2
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
EPA CompTox
DTXSID2021157
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
WIKIPEDIA
PHOSPHINE
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY
HSDB
1233
Created by admin on Mon Mar 31 21:35:03 GMT 2025 , Edited by admin on Mon Mar 31 21:35:03 GMT 2025
PRIMARY