Details
Stereochemistry | ACHIRAL |
Molecular Formula | C17H23ClN2O2 |
Molecular Weight | 322.83 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN1C[C@@H]2CN(C)C[C@H](C1)[C@@H]2OC(=O)C3=CC=C(Cl)C=C3
InChI
InChIKey=PMCPYLGCPSNSLS-FOLVSLTJSA-N
InChI=1S/C17H23ClN2O2/c1-3-20-10-13-8-19(2)9-14(11-20)16(13)22-17(21)12-4-6-15(18)7-5-12/h4-7,13-14,16H,3,8-11H2,1-2H3/t13-,14+,16+
Molecular Formula | C17H23ClN2O2 |
Molecular Weight | 322.83 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Bisaramil, an antiarrhythmic drug was developed as an inhibitor of calcium transport and as a membrane stabilizer. In addition, the drug showed tonic and frequency-dependent block that is most potent against the heart Na+ channel. However, the phase-II for Arrhythmias in Japan was discontinued.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
High-performance liquid chromatographic method for quantitative determination of Yutac, a new antiarrhythmic agent, in dog plasma. | 1985 Mar 22 |
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The effects of bisaramil on experimental arrhythmias. | 1990 Jul-Aug |
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Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog. | 1995 May |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8116453
Six healthy volunteers received an oral dose of 100 mg and an intravenous dose of 35 mg of bisaramil in a cross over study
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30594781
In isolated cardiac myocytes bisaramil directly blocks sodium currents with IC50 values of 13μM
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:05:54 GMT 2023
by
admin
on
Fri Dec 15 16:05:54 GMT 2023
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Record UNII |
FVT2ESG270
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C47793
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377
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C045644
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DTXSID30237569
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3033742
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CHEMBL2103780
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C81430
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FVT2ESG270
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6326
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100000085911
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SUB05848MIG
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89194-77-4
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |