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Details

Stereochemistry ACHIRAL
Molecular Formula C17H23ClN2O2
Molecular Weight 322.83
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BISARAMIL

SMILES

CCN1C[C@@H]2CN(C)C[C@H](C1)[C@@H]2OC(=O)C3=CC=C(Cl)C=C3

InChI

InChIKey=PMCPYLGCPSNSLS-FOLVSLTJSA-N
InChI=1S/C17H23ClN2O2/c1-3-20-10-13-8-19(2)9-14(11-20)16(13)22-17(21)12-4-6-15(18)7-5-12/h4-7,13-14,16H,3,8-11H2,1-2H3/t13-,14+,16+

HIDE SMILES / InChI

Molecular Formula C17H23ClN2O2
Molecular Weight 322.83
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Bisaramil, an antiarrhythmic drug was developed as an inhibitor of calcium transport and as a membrane stabilizer. In addition, the drug showed tonic and frequency-dependent block that is most potent against the heart Na+ channel. However, the phase-II for Arrhythmias in Japan was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
High-performance liquid chromatographic method for quantitative determination of Yutac, a new antiarrhythmic agent, in dog plasma.
1985 Mar 22
The effects of bisaramil on experimental arrhythmias.
1990 Jul-Aug
Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog.
1995 May

Sample Use Guides

Six healthy volunteers received an oral dose of 100 mg and an intravenous dose of 35 mg of bisaramil in a cross over study
Route of Administration: Other
In isolated cardiac myocytes bisaramil directly blocks sodium currents with IC50 values of 13μM
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:05:54 GMT 2023
Edited
by admin
on Fri Dec 15 16:05:54 GMT 2023
Record UNII
FVT2ESG270
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BISARAMIL
INN  
INN  
Official Name English
SYN-3-ETHYL-7-METHYL-3,7-DIAZABICYCLO(3.3.1)NON-9-YL P-CHLOROBENZOATE
Common Name English
bisaramil [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47793
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
Code System Code Type Description
DRUG CENTRAL
377
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
MESH
C045644
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
EPA CompTox
DTXSID30237569
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
PUBCHEM
3033742
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
ChEMBL
CHEMBL2103780
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
NCI_THESAURUS
C81430
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
FDA UNII
FVT2ESG270
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
INN
6326
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
SMS_ID
100000085911
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
EVMPD
SUB05848MIG
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
CAS
89194-77-4
Created by admin on Fri Dec 15 16:05:54 GMT 2023 , Edited by admin on Fri Dec 15 16:05:54 GMT 2023
PRIMARY
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