Details
Stereochemistry | RACEMIC |
Molecular Formula | C13H14O3 |
Molecular Weight | 218.2485 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC(O)COC1=C2C=CC=CC2=CC=C1
InChI
InChIKey=BYNNMWGWFIGTIC-UHFFFAOYSA-N
InChI=1S/C13H14O3/c14-8-11(15)9-16-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,14-15H,8-9H2
Molecular Formula | C13H14O3 |
Molecular Weight | 218.2485 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/4809279Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11489433 | https://www.ncbi.nlm.nih.gov/pubmed/432438 | https://www.ncbi.nlm.nih.gov/pubmed/7895597 | https://www.ncbi.nlm.nih.gov/pubmed/1875045
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4809279
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11489433 | https://www.ncbi.nlm.nih.gov/pubmed/432438 | https://www.ncbi.nlm.nih.gov/pubmed/7895597 | https://www.ncbi.nlm.nih.gov/pubmed/1875045
Propranolol glycol is a major metabolite of propranolol in man with potent anticonvulsant activity. Propranolol glycol appears to be more potent for this effect than propranolol. The onset of action of propranolol glycol is instantaneous but delayed for propranolol. Maximal anticonvulsant activity for propranolol glycol is obtained immediately and for propranolol 10 minutes after administration. The delayed onset of this action of propranolol and the immediate anticonvulsant activity of propranolol glycol strongly suggest that the anticonvulsant properties of propranolol may be related to its conversion to propranolol glycol. Propranolol and propramioiol glycol have a similar spectrum of gross behavioral effects ranging from quietness at low doses to paralysis at high doses. These observations suggest the possibility that propranolol glycol may be contributing to some of the therapeutically significant effects of propranolol in the central nervous system.
CNS Activity
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4809279
The anticonvulsant activity of propranolol glycol was determined by injecting mice with propranolol glycol (2.5-40 mg/kg)
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:50:02 GMT 2023
by
admin
on
Sat Dec 16 10:50:02 GMT 2023
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Record UNII |
FU45BO16RF
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Record Status |
Validated (UNII)
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Related Record | Type | Details | ||
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |
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PARENT -> METABOLITE |
URINE
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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