STEPRONIN SODIUM

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H10NO4S2.Na
Molecular Weight	295.31
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CC(SC(=O)C1=CC=CS1)C(=O)NCC([O-])=O

InChI

InChIKey=LAKRODSFPQQVBB-UHFFFAOYSA-M

InChI=1S/C10H11NO4S2.Na/c1-6(9(14)11-5-8(12)13)17-10(15)7-3-2-4-16-7;/h2-4,6H,5H2,1H3,(H,11,14)(H,12,13);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C10H10NO4S2
Molecular Weight	272.321
Charge	-1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8177972 | https://www.ncbi.nlm.nih.gov/pubmed/3403109 | https://www.ncbi.nlm.nih.gov/pubmed/10616467

Stepronin is clinically used as an expectorant. It inhibits airway secretion in vitro by both decreasing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands. The mucolytic activity of stepronine does not involve the gastric mucous coating and that the drug does not exert adverse effects on the gastric mucosa. It is a new chemical immunosuppressant drug, which has the effect of preventing graft-versus-host-disease (GVHD) in a mouse model. The mechanism by which this compound acts as an immunosuppressant appears to be similar to cyclosporine A (CyA), although, in contrast to CyA, it is not toxic for animals and humans. Stepronin has an antiviral effect as well and is able to block, indirectly, the human immunodeficiency virus–1 (HIV-1) replication in mononuclear cells in vitro.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
regulation of glycoprotein metabolic process 3 Target ID: GO:1903018 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8177972	Inhibitor 8297
transepithelial chloride transport 3 Target ID: GO:0030321 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8177972	Inhibitor 8297

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:32:06 GMT 2023` Edited by `admin` on `Fri Dec 15 16:32:06 GMT 2023`
Record UNII	FR96Q1BI9E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

STEPRONIN SODIUM

Common Name

English

TIOTEN

Common Name

English

Stepronin sodium [WHO-DD]

Common Name

English

STEPRONIN SODIUM SALT [MI]

Common Name

English

SODIUM N-(2-MERCAPTOPROPIONYL)GLYCINE 2-THIOPHENECARBOXYLATE

Systematic Name

English

GLYCINE, N-(1-OXO-2-((2-THIENYLCARBONYL)THIO)PROPYL)-, MONOSODIUM SALT

Systematic Name

English

Code System Code Type Description

PUBCHEM

23691748