POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 1

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 17:36:32 GMT 2025` Edited by `admin` on `Tue Apr 01 17:36:32 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	FP8E4M5I14
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 1

Common Name

English

NGK2

Preferred Name

English

VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV4

Common Name

English

VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV3.1

Common Name

English

Code System Code Type Description

FDA UNII

FP8E4M5I14

Created by admin on Tue Apr 01 17:36:32 GMT 2025 , Edited by admin on Tue Apr 01 17:36:32 GMT 2025

PRIMARY

UNIPROT

P48547

Created by admin on Tue Apr 01 17:36:32 GMT 2025 , Edited by admin on Tue Apr 01 17:36:32 GMT 2025

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_220
N	1_229

Related Record Type Details


					BH3B64OKL9

Dalfampridine

AGONIST -> TARGET


					46P8AHZ243

AUT-00206

POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET

Comments:

AUT00206 positively modulates recombinant human Kv3.1 and Kv3.2 mediated currents, associated with a leftward shift of channel activation. The compound has a weaker effect on Kv3.3 and Kv3.4 channels, and little or no effect on other ion channels tested.

Amount:


					QZ8ETV7QYU

AUT-00201

MODULATOR->TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_44] [1_130] [1_142] [1_158] [1_160] [1_474]				DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_483]				THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL